Abstract：
BACKGROUND: Sexual dysfunction is a multifactorial health condition characterized by distressing disturbances in the sexual response and libido, leading to an inability to maintain penile erection and achieve pleasure. Considering the huge Brazilian biodiversity, many plants are traditionally used for aphrodisiac purposes. However, the use of native medicinal plants as sexual boosters in Brazil has been poorly studied.
OBJECTIVE: This review focuses on the composition, pharmacology, and results of experimental trials of the main native plants used in Brazilian folk medicine with alleged aphrodisiac effects. We aimed to provide a state-of-the-art reference for research on herbs for the treatment of male sexual dysfunction by summarizing and discussing the main studies found.
METHODS: The relevant information was collected by searching keywords (aphrodisiac, sexual tonic, sexual stimulant, sexual vigor stimulant, sexual impotency, erectile dysfunction, etc.) from books containing primary surveys conducted in the original communities and bibliographic surveys prepared by authors linked to the national academic and scientific environment edited in Brazil. Preclinical and clinical studies of the compiled plant species were performed using scientific databases (Scopus, PubMed, SciELO, and SciFinder).
RESULTS: Seventy-four plant species belonging to 44 families used in Brazil to treat sexual dysfunction were compiled from ethnopharmacological literature. Fourteen plants, including Pfaffia glomerata (Spreng.) Pedersen, Aspidosperma quebracho-blanco Schltdl., Anemopaegma arvense (Vell.) Stellfeld ex de Souza, Mimosa pudica L., Heteropterys tomentosa A. Juss., Trichilia catigua A. Juss., and Turnera diffusa Willd. ex Schult. were pharmacologically studied to confirm these therapeutic properties. Probable modes of action include antioxidant and androgenic activities, inhibition of the PDE5 enzyme, increase in NO levels, and activation of dopaminergic and noradrenergic pathways. In addition, several different species popularly known as \"catuaba\" were identified, leading to adulterations and controversial effects.
CONCLUSIONS: The overall results of the present review of Brazilian folk literature reveal that Brazil has a long tradition of using plants with potential aphrodisiac effects. However, further research is required to identify, characterize, and standardize the active ingredients and herbal preparations used in aphrodisiacs.
OBJECTIVE: This review focuses on the composition, pharmacology, and results of experimental trials of the main native plants used in Brazilian folk medicine with alleged aphrodisiac effects. We aimed to provide a state-of-the-art reference for research on herbs for the treatment of male sexual dysfunction by summarizing and discussing the main studies found.
METHODS: The relevant information was collected by searching keywords (aphrodisiac, sexual tonic, sexual stimulant, sexual vigor stimulant, sexual impotency, erectile dysfunction, etc.) from books containing primary surveys conducted in the original communities and bibliographic surveys prepared by authors linked to the national academic and scientific environment edited in Brazil. Preclinical and clinical studies of the compiled plant species were performed using scientific databases (Scopus, PubMed, SciELO, and SciFinder).
RESULTS: Seventy-four plant species belonging to 44 families used in Brazil to treat sexual dysfunction were compiled from ethnopharmacological literature. Fourteen plants, including Pfaffia glomerata (Spreng.) Pedersen, Aspidosperma quebracho-blanco Schltdl., Anemopaegma arvense (Vell.) Stellfeld ex de Souza, Mimosa pudica L., Heteropterys tomentosa A. Juss., Trichilia catigua A. Juss., and Turnera diffusa Willd. ex Schult. were pharmacologically studied to confirm these therapeutic properties. Probable modes of action include antioxidant and androgenic activities, inhibition of the PDE5 enzyme, increase in NO levels, and activation of dopaminergic and noradrenergic pathways. In addition, several different species popularly known as \"catuaba\" were identified, leading to adulterations and controversial effects.
CONCLUSIONS: The overall results of the present review of Brazilian folk literature reveal that Brazil has a long tradition of using plants with potential aphrodisiac effects. However, further research is required to identify, characterize, and standardize the active ingredients and herbal preparations used in aphrodisiacs.
摘要：
背景：性功能障碍是一种多因素的健康状况，其特征是性反应和性欲的困扰，导致无法维持阴茎勃起和获得快乐。考虑到巴西巨大的生物多样性，许多植物传统上用于壮阳目的。然而,在巴西，使用本地药用植物作为性促进剂的研究很少。
目的：这篇综述的重点是，药理学,以及巴西民间医学中使用的主要本地植物的实验试验结果，据称具有壮阳作用。我们旨在通过总结和讨论发现的主要研究，为治疗男性性功能障碍的草药研究提供最新的参考。
方法：通过搜索关键词（壮阳，性补品,性兴奋剂,性活力兴奋剂,性阳痿,勃起功能障碍,等。）来自书籍，其中包含在原始社区进行的主要调查以及作者与巴西编辑的国家学术和科学环境相关的书目调查。使用科学数据库（Scopus，PubMed,SciELO,和SciFinder）。
结果：巴西用于治疗性功能障碍的44个家庭的74种植物是从民族药理学文献中汇编的。14株植物,包括Pfaffiaglomerata(Sprng.)Pedersen,Aspidospermaquebracho-blancoSchltdl.,Anemopaegmaarvense（Vell。)Stellfeld前任deSouza,含羞草，杂种。,TrichiliacatiguaA.Juss.,还有TurneradiffusaWilld.前Schult.进行了药理学研究以证实这些治疗特性。可能的作用方式包括抗氧化和雄激素活性，抑制PDE5酶，NO水平增加，以及多巴胺能和去甲肾上腺素能途径的激活。此外,确定了几种不同的物种，通常被称为“catuaba”，导致掺假和有争议的影响。
结论：本巴西民间文学综述的总体结果表明，巴西在使用具有潜在壮阳作用的植物方面有着悠久的传统。然而,需要进一步的研究来确定，表征，并规范壮阳药中使用的活性成分和草药制剂。
目的：这篇综述的重点是，药理学,以及巴西民间医学中使用的主要本地植物的实验试验结果，据称具有壮阳作用。我们旨在通过总结和讨论发现的主要研究，为治疗男性性功能障碍的草药研究提供最新的参考。
方法：通过搜索关键词（壮阳，性补品,性兴奋剂,性活力兴奋剂,性阳痿,勃起功能障碍,等。）来自书籍，其中包含在原始社区进行的主要调查以及作者与巴西编辑的国家学术和科学环境相关的书目调查。使用科学数据库（Scopus，PubMed,SciELO,和SciFinder）。
结果：巴西用于治疗性功能障碍的44个家庭的74种植物是从民族药理学文献中汇编的。14株植物,包括Pfaffiaglomerata(Sprng.)Pedersen,Aspidospermaquebracho-blancoSchltdl.,Anemopaegmaarvense（Vell。)Stellfeld前任deSouza,含羞草，杂种。,TrichiliacatiguaA.Juss.,还有TurneradiffusaWilld.前Schult.进行了药理学研究以证实这些治疗特性。可能的作用方式包括抗氧化和雄激素活性，抑制PDE5酶，NO水平增加，以及多巴胺能和去甲肾上腺素能途径的激活。此外,确定了几种不同的物种，通常被称为“catuaba”，导致掺假和有争议的影响。
结论：本巴西民间文学综述的总体结果表明，巴西在使用具有潜在壮阳作用的植物方面有着悠久的传统。然而,需要进一步的研究来确定，表征，并规范壮阳药中使用的活性成分和草药制剂。
