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Abstract：
Interferon induced with helicase C domain 1 (IFIH1) single-nucleotide polymorphisms (SNP) rs1990760, rs3747517, and rs10930046 have been shown to be closely related to the risk of autoimmune diseases. The aim of this study was firstly to examine the association of the rs1990760 with type 1 diabetes (T1D) in a Chinese population. Secondly, to assess the association of SNP rs1990760, rs3747517, and rs10930046 with autoimmune diseases susceptibility.
A total of 1,273 T1D patients and 1,010 healthy control subjects in a Chinese population were enrolled in this case-control study. Subsequently, we performed a meta-analysis on the association of the SNP rs1990760, rs3747517, and rs10930046 in the IFIH1 gene with susceptibility to autoimmune diseases. The random and fixed genetic effects models were used to evaluate the association and the effect sizes, including odds ratios (OR) and 95% confidence intervals (CI). Stratification analyses based on ethnicity and the type of autoimmune diseases were performed.
IFIH1 SNP rs1990760 was not associated with a significant risk of T1D in the Chinese population in the case-control study. A total of 35 studies including 70,966 patients and 124,509 controls were identified and included in the meta-analysis. The results displayed significant associations between IFIH1 rs1990760 A allele and rs3747517 C allele and autoimmune diseases risk (OR=1.09, 95% CI: 1.01~1.17; OR=1.24, 95% CI: 1.15~1.25, respectively). Stratified analysis indicated a significant association rs1990760 and rs3747517 with autoimmune diseases risk in the Caucasian population (OR=1.11, 95% CI: 1.02~1.20, OR=1.29, 95% CI: 1.18~1.41, respectively).
This study revealed no association between IFIH1 SNP rs1990760 and T1D in Chinese. Furthermore, the meta-analysis indicated that rs1990760 and rs3747517 polymorphisms, confer susceptibility to autoimmune diseases, especially in the Caucasian population.
A total of 1,273 T1D patients and 1,010 healthy control subjects in a Chinese population were enrolled in this case-control study. Subsequently, we performed a meta-analysis on the association of the SNP rs1990760, rs3747517, and rs10930046 in the IFIH1 gene with susceptibility to autoimmune diseases. The random and fixed genetic effects models were used to evaluate the association and the effect sizes, including odds ratios (OR) and 95% confidence intervals (CI). Stratification analyses based on ethnicity and the type of autoimmune diseases were performed.
IFIH1 SNP rs1990760 was not associated with a significant risk of T1D in the Chinese population in the case-control study. A total of 35 studies including 70,966 patients and 124,509 controls were identified and included in the meta-analysis. The results displayed significant associations between IFIH1 rs1990760 A allele and rs3747517 C allele and autoimmune diseases risk (OR=1.09, 95% CI: 1.01~1.17; OR=1.24, 95% CI: 1.15~1.25, respectively). Stratified analysis indicated a significant association rs1990760 and rs3747517 with autoimmune diseases risk in the Caucasian population (OR=1.11, 95% CI: 1.02~1.20, OR=1.29, 95% CI: 1.18~1.41, respectively).
This study revealed no association between IFIH1 SNP rs1990760 and T1D in Chinese. Furthermore, the meta-analysis indicated that rs1990760 and rs3747517 polymorphisms, confer susceptibility to autoimmune diseases, especially in the Caucasian population.
摘要：
■干扰素诱导的解旋酶C结构域1（IFIH1）单核苷酸多态性（SNP）rs1990760，rs3747517和rs10930046已显示与自身免疫性疾病的风险密切相关。这项研究的目的是首先检查rs1990760与中国人群中1型糖尿病（T1D）的相关性。其次,评估SNPrs1990760，rs3747517和rs10930046与自身免疫性疾病易感性的关联。
■共有1,273名T1D患者和1,010名健康对照受试者参加了这项病例对照研究。随后，我们对IFIH1基因中SNPrs1990760,rs3747517和rs10930046与自身免疫性疾病易感性的相关性进行了荟萃分析.随机和固定遗传效应模型用于评估关联和效应大小，包括比值比(OR)和95%置信区间(CI)。进行了基于种族和自身免疫性疾病类型的分层分析。
■在病例对照研究中，IFIH1SNPrs1990760与中国人群中T1D的显着风险无关。总共确定了35项研究，包括70,966名患者和124,509名对照，并将其纳入荟萃分析。结果显示IFIH1rs1990760A等位基因和rs3747517C等位基因与自身免疫性疾病风险显著相关(OR=1.09,95%CI:1.01~1.17;OR=1.24,95%CI:1.15~1.25)。分层分析显示rs1990760和rs3747517与高加索人群自身免疫性疾病风险显著相关(OR=1.11,95%CI:1.02~1.20,OR=1.29,95%CI:1.18~1.41)。
■这项研究显示中国人IFIH1SNPrs1990760和T1D之间没有关联。此外，荟萃分析表明，rs1990760和rs3747517多态性，赋予自身免疫性疾病的易感性，尤其是在高加索人群中。
■共有1,273名T1D患者和1,010名健康对照受试者参加了这项病例对照研究。随后，我们对IFIH1基因中SNPrs1990760,rs3747517和rs10930046与自身免疫性疾病易感性的相关性进行了荟萃分析.随机和固定遗传效应模型用于评估关联和效应大小，包括比值比(OR)和95%置信区间(CI)。进行了基于种族和自身免疫性疾病类型的分层分析。
■在病例对照研究中，IFIH1SNPrs1990760与中国人群中T1D的显着风险无关。总共确定了35项研究，包括70,966名患者和124,509名对照，并将其纳入荟萃分析。结果显示IFIH1rs1990760A等位基因和rs3747517C等位基因与自身免疫性疾病风险显著相关(OR=1.09,95%CI:1.01~1.17;OR=1.24,95%CI:1.15~1.25)。分层分析显示rs1990760和rs3747517与高加索人群自身免疫性疾病风险显著相关(OR=1.11,95%CI:1.02~1.20,OR=1.29,95%CI:1.18~1.41)。
■这项研究显示中国人IFIH1SNPrs1990760和T1D之间没有关联。此外，荟萃分析表明，rs1990760和rs3747517多态性，赋予自身免疫性疾病的易感性，尤其是在高加索人群中。
