Abstract：
OBJECTIVE: To evaluate the changes in peripapillary microvascularity in idiopathic intracranial hypertension (IIH) and optic disc drusen (ODD) patients, by comparing them with those in healthy individuals, via optical coherence tomography angiography (OCTA).
METHODS: Sixty-two eyes of 33 patients with ODD, 58 eyes of 30 patients with IIH, and 70 eyes of 70 healthy people were imaged for 6 × 6-mm optic disc scans on a spectral-domain OCTA. Vascular densities in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) of ODD, IIH, and healthy eyes were compared with a one-way analysis of variance. Post-hoc analysis was performed with the Gabriel test.
RESULTS: There was a significant decrease in peripapillary vessel density in SCP, DCP, and CC in patients with IIH compared to the control group (p < 0.05). In ODD patients, especially peripapillary vessel density in DCP was significantly reduced compared to the control group (p < 0.05). Peripapillary vessel density in DCP was significantly lower in the IIH group than ODD group (p < 0.05).
CONCLUSIONS: Peripapillary vascular density may be affected during the course of the disease in both IIH and ODD. Compared to healthy individuals, the decrease in vascular density in these patients and the consequent decrease in perfusion in the peripapillary region may guide the pathogenesis of the complications in the course of these two diseases. Although vascular density in DCP and CC differs significantly between IIH and ODD, case-controlled studies are needed to evaluate the role of OCTA in the differential diagnosis of IHH and ODD.
METHODS: Sixty-two eyes of 33 patients with ODD, 58 eyes of 30 patients with IIH, and 70 eyes of 70 healthy people were imaged for 6 × 6-mm optic disc scans on a spectral-domain OCTA. Vascular densities in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) of ODD, IIH, and healthy eyes were compared with a one-way analysis of variance. Post-hoc analysis was performed with the Gabriel test.
RESULTS: There was a significant decrease in peripapillary vessel density in SCP, DCP, and CC in patients with IIH compared to the control group (p < 0.05). In ODD patients, especially peripapillary vessel density in DCP was significantly reduced compared to the control group (p < 0.05). Peripapillary vessel density in DCP was significantly lower in the IIH group than ODD group (p < 0.05).
CONCLUSIONS: Peripapillary vascular density may be affected during the course of the disease in both IIH and ODD. Compared to healthy individuals, the decrease in vascular density in these patients and the consequent decrease in perfusion in the peripapillary region may guide the pathogenesis of the complications in the course of these two diseases. Although vascular density in DCP and CC differs significantly between IIH and ODD, case-controlled studies are needed to evaluate the role of OCTA in the differential diagnosis of IHH and ODD.
摘要：
目的：评估特发性颅内高压（IIH）和视盘玻璃疣（ODD）患者乳头周围微血管的变化，通过将它们与健康个体进行比较，通过光学相干断层扫描血管造影（OCTA）。
方法：33例ODD患者62只眼，30例IIH患者的58眼，70名健康人的70只眼睛在光谱域OCTA上进行了6×6-mm视盘扫描成像。浅表毛细血管丛（SCP）中的血管密度，深毛细血管丛（DCP），和ODD的脉络膜毛细血管(CC)，IIH,和健康的眼睛进行了单向方差分析比较。事后分析用Gabriel试验进行。
结果：SCP的乳头周围血管密度显著降低，DCP,与对照组相比，IIH患者的CC和CC（p<0.05）。在ODD患者中，与对照组相比，DCP的乳头周围血管密度显着降低（p<0.05）。IIH组DCP的乳头周围血管密度明显低于ODD组（p<0.05）。
结论：在IIH和ODD的病程中，乳头周围血管密度均可能受到影响。与健康的个体相比，这些患者血管密度的降低以及随之而来的乳头周围区域灌注的减少可能指导这两种疾病过程中并发症的发病机理。虽然DCP和CC的血管密度在IIH和ODD之间有显著差异,需要病例对照研究来评估OCTA在IHH和ODD鉴别诊断中的作用.
方法：33例ODD患者62只眼，30例IIH患者的58眼，70名健康人的70只眼睛在光谱域OCTA上进行了6×6-mm视盘扫描成像。浅表毛细血管丛（SCP）中的血管密度，深毛细血管丛（DCP），和ODD的脉络膜毛细血管(CC)，IIH,和健康的眼睛进行了单向方差分析比较。事后分析用Gabriel试验进行。
结果：SCP的乳头周围血管密度显著降低，DCP,与对照组相比，IIH患者的CC和CC（p<0.05）。在ODD患者中，与对照组相比，DCP的乳头周围血管密度显着降低（p<0.05）。IIH组DCP的乳头周围血管密度明显低于ODD组（p<0.05）。
结论：在IIH和ODD的病程中，乳头周围血管密度均可能受到影响。与健康的个体相比，这些患者血管密度的降低以及随之而来的乳头周围区域灌注的减少可能指导这两种疾病过程中并发症的发病机理。虽然DCP和CC的血管密度在IIH和ODD之间有显著差异,需要病例对照研究来评估OCTA在IHH和ODD鉴别诊断中的作用.
