Abstract：
Stroke is a serious cerebrovascular disease that causes post-stress depression and death. Stress and inflammation have pivotal roles in the induction of the disease. Several drugs and agents have been used for the treatment of disease, but their uses are faced with limitations owing to their side effects. Natural agents are more efficient for the treatment of stroke due to lower toxicity and their pharmaceutical properties. Sake yeast or Japanese rice wine is an antioxidant compound that could be used to treat stroke and post-stress depression. This study evaluates the effects of sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion. Rats were divided into four groups, including 1) control: without bilateral common carotid artery occlusion (BCCAO) and sake supplement, 2) Ischemia group: rats induced with BCCAO and lack of therapeutic supplement, and 3 and 4) Ischemia + sake groups: rats induced with BCCAO and treated with 25 and 50 mg/kg sake yeast, respectively. Depressive-like behaviors antioxidant enzymes activities were assessed. The induction of stroke increased oxidant status, inflammatory parameters, and depressive-like behaviors, while the administration of sake could decrease inflammation, depressive-like behaviors, and oxidant status and increase antioxidant enzymes. The yeast could be used as a supplement in combination with other drugs to treat stroke.
摘要：
中风是一种严重的脑血管疾病，可导致应激后抑郁和死亡。应激和炎症在疾病的诱导中具有关键作用。几种药物和药剂已被用于治疗疾病，但是由于副作用，它们的用途面临着限制。由于较低的毒性和它们的药物性质,天然药剂对于治疗中风更有效。清酒酵母或日本米酒是一种抗氧化剂，可用于治疗中风和压力后抑郁症。这项研究评估了清酒酵母对抑郁样行为的影响，大鼠全脑缺血/再灌注模型的氧化应激和炎症参数。大鼠分为四组,包括1)对照:没有双侧颈总动脉闭塞(BCCAO)和清酒补充,2）缺血组：BCCAO诱导大鼠，缺乏治疗性补充，和3和4）缺血清酒组：用BCCAO诱导并用25和50mg/kg清酒酵母处理的大鼠，分别。评估了抑郁样行为抗氧化酶的活性。中风的诱导增加了氧化剂状态，炎症参数，和类似抑郁的行为，虽然清酒的给药可以减少炎症，类似抑郁的行为，和氧化剂状态和增加抗氧化酶。酵母可以作为补充剂与其他药物联合使用来治疗中风。
