Abstract：
Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN-induced skin infections with long-term transdermal administration. Using the Langmuir-Blodgett (LB) technique, a simple method for depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled coating layers, uniform and high coverage, and a straightforward fabrication process. This provides MNs with a fast-acting and long-lasting antibacterial effect. This study demonstrates that antibacterial MNs achieve superior bacterial elimination in vitro and in vivo without sacrificing payload capacity, drug release, or mechanical strength. It is believed that such a functional nanoparticle coating technique offers a platform for the expansion of MNs function, especially in long-term transdermal drug delivery fields.
摘要：
微针(MN)已经成为用于微创经皮药物递送装置的通用平台。然而,长期经皮给药对MN诱导的皮肤感染存在担忧。使用Langmuir-Blodgett(LB)技术，我们开发了一种简单的方法来沉积各种形状的抗菌纳米颗粒，尺寸,和组合物到MN上。此策略优于常规浸涂技术，包括受控涂层，统一和高覆盖率，和一个简单的制造过程。这为MN提供了快速作用和持久的抗菌作用。我们的研究表明，抗菌MNs在体外和体内实现了优异的细菌消除，而不牺牲有效载荷能力，药物释放，或机械强度。我们认为这种功能性纳米粒子涂层技术为MNs功能的扩展提供了平台,特别是在长期经皮给药领域。本文受版权保护。保留所有权利。
