PDF(Pubmed)
Abstract：
Epilepsy is a common symptom in diffuse lower-grade glioma (DLGG). The specific role of white matter (WM) alteration in patients with glioma-related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE.
Diffusion-weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non-GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups.
Compared with HC, both GRE and non-GRE showed decreased FA in contralateral inferior fronto-occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal-parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non-GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all p < 0.05 after Bonferroni correction).
This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal-parietal and limbic networks. Moreover, the preserved integrity in contralateral CST and server decreased nodal betweenness in PCL may be potential neuroimaging markers underlying the occurrence of presurgical seizures of GRE.
Diffusion-weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non-GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups.
Compared with HC, both GRE and non-GRE showed decreased FA in contralateral inferior fronto-occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal-parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non-GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all p < 0.05 after Bonferroni correction).
This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal-parietal and limbic networks. Moreover, the preserved integrity in contralateral CST and server decreased nodal betweenness in PCL may be potential neuroimaging markers underlying the occurrence of presurgical seizures of GRE.
摘要：
目的：癫痫是弥漫性低度胶质瘤（DLGG）的常见症状。脑白质（WM）改变在神经胶质瘤相关性癫痫（GRE）患者中的具体作用尚不清楚。本研究旨在调查WM束的重组以及与GRE相关的结构网络的变化。
方法：收集了70例左额叶DLGG患者（GRE=33，非GRE=37）和41例健康对照（HC）的扩散加权图像。使用TractSeg的示踪测定法应用于节段束，并量化沿每个束的分数各向异性（FA）。使用约束球形反卷积和概率束图法构建结构网络。比较三组的FA和网络特性。
结果：与HC相比，GRE和non-GRE均显示对侧额枕骨下束FA降低，上纵束II和弓形束，额叶-顶叶和边缘网络对侧节点的节点效率增加，而颞叶背侧和前端中额回（rMFG）节点的度中心性和介数中心性降低。此外,当比较GRE和非GRE时，GRE中对侧皮质脊髓束（CST）的FA增加，中央小叶旁小叶（PCL）的介数中心性降低（Bonferroni校正后所有p<0.05）。
结论：这项研究表明，左额DLGG患者表现出复杂的WM重组，改变的区域主要集中在语言上，额叶-顶叶和边缘网络。此外，保留的对侧CST完整性和降低的PCL服务器节点间值可能是GRE术前癫痫发作的潜在神经影像学标志物.
方法：收集了70例左额叶DLGG患者（GRE=33，非GRE=37）和41例健康对照（HC）的扩散加权图像。使用TractSeg的示踪测定法应用于节段束，并量化沿每个束的分数各向异性（FA）。使用约束球形反卷积和概率束图法构建结构网络。比较三组的FA和网络特性。
结果：与HC相比，GRE和non-GRE均显示对侧额枕骨下束FA降低，上纵束II和弓形束，额叶-顶叶和边缘网络对侧节点的节点效率增加，而颞叶背侧和前端中额回（rMFG）节点的度中心性和介数中心性降低。此外,当比较GRE和非GRE时，GRE中对侧皮质脊髓束（CST）的FA增加，中央小叶旁小叶（PCL）的介数中心性降低（Bonferroni校正后所有p<0.05）。
结论：这项研究表明，左额DLGG患者表现出复杂的WM重组，改变的区域主要集中在语言上，额叶-顶叶和边缘网络。此外，保留的对侧CST完整性和降低的PCL服务器节点间值可能是GRE术前癫痫发作的潜在神经影像学标志物.
