Abstract：
This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD).
The Web of Science database (2007-2022) was searched using the search terms \"phytochemicals\" and \"PTSD,\" and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted.
Three hundred and one articles were included in the analysis of published research, which has surged since 2015 with nearly half of all relevant articles coming from North America. The category is dominated by neuroscience and neurology, with two journals, Addictive Behaviors and Drug and Alcohol Dependence, publishing the greatest number of papers on these topics. Most studies focused on psychedelic intervention for PTSD. Three timelines show an \"ebb and flow\" phenomenon between \"substance use/marijuana abuse\" and \"psychedelic medicine/medicinal cannabis.\" Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover, serotonin levels, and brain-derived neurotrophic factor expression.
Research on phytochemicals and PTSD is unevenly distributed across countries/regions, disciplines, and journals. Since 2015, the research paradigm shifted to constitute the mainstream of psychedelic research thus far, leading to the exploration of botanical active ingredients and molecular mechanisms. Other studies focus on anti-oxidative stress and anti-inflammation. Please cite this article as: Gao B, Qu YC, Cai MY, Zhang YY, Lu HT, Li HX, Tang YX, Shen H. Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace. J Integr Med. 2023; 21(4):385-396.
The Web of Science database (2007-2022) was searched using the search terms \"phytochemicals\" and \"PTSD,\" and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted.
Three hundred and one articles were included in the analysis of published research, which has surged since 2015 with nearly half of all relevant articles coming from North America. The category is dominated by neuroscience and neurology, with two journals, Addictive Behaviors and Drug and Alcohol Dependence, publishing the greatest number of papers on these topics. Most studies focused on psychedelic intervention for PTSD. Three timelines show an \"ebb and flow\" phenomenon between \"substance use/marijuana abuse\" and \"psychedelic medicine/medicinal cannabis.\" Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover, serotonin levels, and brain-derived neurotrophic factor expression.
Research on phytochemicals and PTSD is unevenly distributed across countries/regions, disciplines, and journals. Since 2015, the research paradigm shifted to constitute the mainstream of psychedelic research thus far, leading to the exploration of botanical active ingredients and molecular mechanisms. Other studies focus on anti-oxidative stress and anti-inflammation. Please cite this article as: Gao B, Qu YC, Cai MY, Zhang YY, Lu HT, Li HX, Tang YX, Shen H. Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace. J Integr Med. 2023; 21(4):385-396.
摘要：
目的：本研究调查了植物化学治疗创伤后应激障碍（PTSD）的研究趋势。
方法：使用搜索词“植物化学物质”和“PTSD”搜索WebofScience数据库（2007-2022），\"和相关文献进行了汇编。进行网络聚类共现分析和定性叙事综述。
结果：对已发表研究的分析中包含了三百零一篇文章，自2015年以来，这一数字激增，近一半的相关文章来自北美。该类别以神经科学和神经病学为主，有两本日记，成瘾行为与药物和酒精依赖，发表关于这些主题的论文数量最多。大多数研究集中在对PTSD的迷幻干预上。三个时间表显示了“物质使用/大麻滥用”和“迷幻药物/药用大麻”之间的“潮起潮落”现象。“其他植物化学物质占研究的一小部分，专注于神经类固醇周转等主题，血清素水平,和脑源性神经营养因子的表达。
结论：关于植物化学物质和创伤后应激障碍的研究在各个国家/地区分布不均，学科,和期刊。自2015年以来，研究范式转变为构成迄今为止迷幻研究的主流，导致植物活性成分和分子机制的探索。其他研究集中在抗氧化应激和抗炎。请引用这篇文章:高B,曲YC,蔡MY,张YY,LuHT,李HX,唐YX,ShenH.创伤后应激障碍的植物化学干预：使用CiteSpace进行集群共现网络分析。JIntegrMed。2023年；Epub领先于印刷。
方法：使用搜索词“植物化学物质”和“PTSD”搜索WebofScience数据库（2007-2022），\"和相关文献进行了汇编。进行网络聚类共现分析和定性叙事综述。
结果：对已发表研究的分析中包含了三百零一篇文章，自2015年以来，这一数字激增，近一半的相关文章来自北美。该类别以神经科学和神经病学为主，有两本日记，成瘾行为与药物和酒精依赖，发表关于这些主题的论文数量最多。大多数研究集中在对PTSD的迷幻干预上。三个时间表显示了“物质使用/大麻滥用”和“迷幻药物/药用大麻”之间的“潮起潮落”现象。“其他植物化学物质占研究的一小部分，专注于神经类固醇周转等主题，血清素水平,和脑源性神经营养因子的表达。
结论：关于植物化学物质和创伤后应激障碍的研究在各个国家/地区分布不均，学科,和期刊。自2015年以来，研究范式转变为构成迄今为止迷幻研究的主流，导致植物活性成分和分子机制的探索。其他研究集中在抗氧化应激和抗炎。请引用这篇文章:高B,曲YC,蔡MY,张YY,LuHT,李HX,唐YX,ShenH.创伤后应激障碍的植物化学干预：使用CiteSpace进行集群共现网络分析。JIntegrMed。2023年；Epub领先于印刷。
