PDF(Pubmed)
Abstract：
Ezrin is the cytoskeletal organizer and functions in the modulation of membrane-cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell-cell adhesion and movement, as well as cell survival. Ezrin plays a critical role in regulating tumor metastasis through interaction with other binding proteins. Notably, Ezrin has been reported to interact with immune cells, allowing tumor cells to escape immune attack in metastasis. Here, we review the main functions of Ezrin, the mechanisms through which it acts, its role in tumor metastasis, and its potential as a therapeutic target.
摘要：
Ezrin是细胞骨架的组织者，在膜-细胞骨架相互作用的调节中起作用，细胞形状和结构的维护，调节细胞间的粘附和运动，以及细胞存活。Ezrin通过与其他结合蛋白的相互作用在调节肿瘤转移中起关键作用。值得注意的是,据报道，Ezrin与免疫细胞相互作用，允许肿瘤细胞在转移中逃避免疫攻击。这里,我们回顾了Ezrin的主要功能，它发挥作用的机制，它在肿瘤转移中的作用，以及它作为治疗靶点的潜力。
