METHODS: With permission of the Surveillance, Epidemiology and End Results (SEER) program of the United States National Cancer Institute, clinicopathological information of women diagnosed with EC and following OC were analyzed. Incidence of OC and survival according to the surgical approach were studied. Primary analysis was conducted in women up to and including the age of 49 years.
RESULTS: A total of 116 patients up to the age of 49 years were diagnosed with EC and following OC. In this group of patients, no differences in incidence (IRR 0.9, CI 0.56-1.49, p = 0.66) or survival rates (p = 0.71) were found comparing ovarian preservation and bilateral salpingo-oophorectomy (BSO) performance. In an overall analysis of women diagnosed with EC and following OC at any age, incidence of OC did not differ between groups (IRR 1.07, CI 0.83-1.39, p = 0.59) yet when including patients older than 49 years old survival rates were shorter in ovarian preservation patients compared to patients with BSO performed as part of their EC treatment.
CONCLUSIONS: Ovarian preservation in EC patients under the age of 49 years may be considered safe, with no impact on OC incidence or survival, benefiting longer natural hormonal status.
方法:经监督许可,美国国家癌症研究所的流行病学和最终结果(SEER)计划,分析诊断为EC和OC的女性的临床病理信息。根据手术方式研究了OC的发生率和生存率。对49岁以下和包括49岁的女性进行了初步分析。
结果:共有116名49岁以下的患者被诊断为EC和OC。在这组患者中,卵巢保存和双侧输卵管卵巢切除术(BSO)的发生率(IRR0.9,CI0.56-1.49,p=0.66)或生存率(p=0.71)无差异.在对任何年龄诊断为EC和OC的女性的总体分析中,OC的发生率在组间没有差异(IRR1.07,CI0.83-1.39,p=0.59),但当包括49岁以上患者在内的保留卵巢患者的生存率低于作为EC治疗一部分的BSO患者时.
结论:在49岁以下的EC患者中保留卵巢可能被认为是安全的,对OC发病率或生存率没有影响,受益于更长的自然荷尔蒙状态。