Abstract：
BACKGROUND: Meniere\'s disease (MD) is a complex disease that can severely affect the quality of life. In this systematic review and meta-analysis, we aimed to investigate the effect of vestibular rehabilitation (VR) versus control/other interventions on the quality of life in patients with MD.
METHODS: We searched six electronic databases (PubMed/MEDLINE, Web of Science, EMBASE, Scopus, ProQuest, CENTRAL) from inception to September 30, 2022 with no language restriction for publications comparing the effect of VR with control/ other interventions in patients with MD. The primary outcome was quality of life assessed by dizziness handicap inventory (DHI).
RESULTS: Overall, three studies with a total of 465 patients were included in the meta-analysis. All the included studies reported immediate-term DHI scores. A medium effect (standardized mean difference [SMD] = - 0.58, 95% confidence interval [CI] - 1.12; - 0.05) was observed favoring the use of VR to improve DHI scores in patients with MD in the immediate term. Moreover, there was severe heterogeneity in immediate DHI scores among the included studies (χ2 = 22.33, P = 0.00, I2 = 82.1%).
CONCLUSIONS: VR rehabilitation can improve the quality of life in patients with MD immediately after treatment. Since all the included studies had a high risk of bias and none had long-term follow-ups, further high-quality research is required to determine the short-, intermediate-, and long-term effects of VR compared to control/other interventions.
METHODS: We searched six electronic databases (PubMed/MEDLINE, Web of Science, EMBASE, Scopus, ProQuest, CENTRAL) from inception to September 30, 2022 with no language restriction for publications comparing the effect of VR with control/ other interventions in patients with MD. The primary outcome was quality of life assessed by dizziness handicap inventory (DHI).
RESULTS: Overall, three studies with a total of 465 patients were included in the meta-analysis. All the included studies reported immediate-term DHI scores. A medium effect (standardized mean difference [SMD] = - 0.58, 95% confidence interval [CI] - 1.12; - 0.05) was observed favoring the use of VR to improve DHI scores in patients with MD in the immediate term. Moreover, there was severe heterogeneity in immediate DHI scores among the included studies (χ2 = 22.33, P = 0.00, I2 = 82.1%).
CONCLUSIONS: VR rehabilitation can improve the quality of life in patients with MD immediately after treatment. Since all the included studies had a high risk of bias and none had long-term follow-ups, further high-quality research is required to determine the short-, intermediate-, and long-term effects of VR compared to control/other interventions.
摘要：
背景：梅尼埃病（MD）是一种复杂的疾病，可严重影响生活质量。在这篇系统综述和荟萃分析中，我们旨在探讨前庭康复(VR)与对照/其他干预措施对MD患者生活质量的影响.
方法：我们搜索了六个电子数据库(PubMed/MEDLINE，WebofScience,EMBASE,Scopus,ProQuest,CENTRAL）从开始到2022年9月30日，对出版物没有语言限制，比较VR与对照/其他干预措施对MD患者的影响。主要结果是通过头晕障碍量表（DHI）评估的生活质量。
结果：总体而言，三项研究共465例患者纳入荟萃分析.所有纳入的研究均报告了近期DHI评分。观察到中等效果（标准化平均差[SMD]=-0.58，95％置信区间[CI]-1.12；-0.05）有利于使用VR改善MD患者的DHI评分。此外，纳入研究的即时DHI评分存在严重异质性(χ2=22.33,P=0.00,I2=82.1%).
结论：VR康复可以改善MD患者治疗后即刻的生活质量。由于所有纳入的研究都有很高的偏倚风险，并且没有一项进行长期随访，需要进一步高质量的研究来确定短期，中介-，与对照/其他干预措施相比，VR的长期影响。
方法：我们搜索了六个电子数据库(PubMed/MEDLINE，WebofScience,EMBASE,Scopus,ProQuest,CENTRAL）从开始到2022年9月30日，对出版物没有语言限制，比较VR与对照/其他干预措施对MD患者的影响。主要结果是通过头晕障碍量表（DHI）评估的生活质量。
结果：总体而言，三项研究共465例患者纳入荟萃分析.所有纳入的研究均报告了近期DHI评分。观察到中等效果（标准化平均差[SMD]=-0.58，95％置信区间[CI]-1.12；-0.05）有利于使用VR改善MD患者的DHI评分。此外，纳入研究的即时DHI评分存在严重异质性(χ2=22.33,P=0.00,I2=82.1%).
结论：VR康复可以改善MD患者治疗后即刻的生活质量。由于所有纳入的研究都有很高的偏倚风险，并且没有一项进行长期随访，需要进一步高质量的研究来确定短期，中介-，与对照/其他干预措施相比，VR的长期影响。
