Abstract：
Malnutrition is frequent in patients with chronic kidney disease (CKD) and has a negative impact on morbidity, mortality, and quality of life. The objective of this study was to assess the value of the Global Leadership Initiative for Malnutrition (GLIM) criteria to predict hospitalizations and mortality in candidates to kidney transplant during their first year on the waiting list.
This was a post hoc analysis of 368 patients with advanced CKD. The main study variables were malnutrition, according to the GLIM criteria; number of hospital admissions during the first year on the waiting list; and mortality at the end of follow-up. Kaplan-Meier survival curves and binary logistic regression were performed, adjusting for age, frailty status, handgrip strength, and Charlson Index as potential confounders.
The prevalence of malnutrition was 32.6%. Malnutrition was associated with increased risk of hospitalizations during the first year on the waiting list (odds ratio [OR] = 3.33 [95% CI = 1.34-8.26]), which persisted after adjustment for age and frailty status (adjusted OR = 3.61 [95% CI = 1.38-10.7]), age and handgrip strength (adjusted OR = 3.39 [95% CI = 1.3-8.85]), and age and Charlson Index (adjusted OR = 3.25 [95% CI = 1.29-8.13]).
Malnutrition according to the GLIM criteria was highly prevalent in patients with CKD and was associated with a threefold increased risk of hospitalizations during the first year on the waiting list; these associations remained significant after adjusting for age, frailty status, handgrip strength, and comorbidities.
This was a post hoc analysis of 368 patients with advanced CKD. The main study variables were malnutrition, according to the GLIM criteria; number of hospital admissions during the first year on the waiting list; and mortality at the end of follow-up. Kaplan-Meier survival curves and binary logistic regression were performed, adjusting for age, frailty status, handgrip strength, and Charlson Index as potential confounders.
The prevalence of malnutrition was 32.6%. Malnutrition was associated with increased risk of hospitalizations during the first year on the waiting list (odds ratio [OR] = 3.33 [95% CI = 1.34-8.26]), which persisted after adjustment for age and frailty status (adjusted OR = 3.61 [95% CI = 1.38-10.7]), age and handgrip strength (adjusted OR = 3.39 [95% CI = 1.3-8.85]), and age and Charlson Index (adjusted OR = 3.25 [95% CI = 1.29-8.13]).
Malnutrition according to the GLIM criteria was highly prevalent in patients with CKD and was associated with a threefold increased risk of hospitalizations during the first year on the waiting list; these associations remained significant after adjusting for age, frailty status, handgrip strength, and comorbidities.
摘要：
目的：慢性肾脏病（CKD）患者经常发生营养不良，对发病率有负面影响，死亡率,和生活质量。这项研究的目的是评估全球领导力营养不良倡议（GLIM）标准的价值，以预测在等待名单的第一年肾移植候选人的住院和死亡率。
方法：对368例晚期CKD患者进行事后分析。根据GLIM标准，主要研究变量为营养不良，等待名单上第一年的住院人数，以及随访结束时的死亡率。进行Kaplan-Meier存活曲线和二元逻辑回归，调整年龄，脆弱状态，握力,和Charlson指数作为潜在的混杂因素。
结果：营养不良的患病率为32.6％。营养不良与等待名单第一年住院风险增加相关（OR=3.33[95CI1.34至8.26]），在调整年龄和虚弱状态后仍然存在(调整后的OR=3.61[95CI1.38至10.7])，年龄和握力（调整后的OR=3.39[95CI1.3至8.85]），以及年龄和Charlson指数（调整后的OR=3.25[95CI1.29至8.13]）。
结论：根据GLIM标准的营养不良在CKD患者中非常普遍，并与等待名单上第一年的住院风险增加3倍相关；这些关联在调整年龄后仍然很重要，脆弱状态，握力,和合并症。本文受版权保护。保留所有权利。
方法：对368例晚期CKD患者进行事后分析。根据GLIM标准，主要研究变量为营养不良，等待名单上第一年的住院人数，以及随访结束时的死亡率。进行Kaplan-Meier存活曲线和二元逻辑回归，调整年龄，脆弱状态，握力,和Charlson指数作为潜在的混杂因素。
结果：营养不良的患病率为32.6％。营养不良与等待名单第一年住院风险增加相关（OR=3.33[95CI1.34至8.26]），在调整年龄和虚弱状态后仍然存在(调整后的OR=3.61[95CI1.38至10.7])，年龄和握力（调整后的OR=3.39[95CI1.3至8.85]），以及年龄和Charlson指数（调整后的OR=3.25[95CI1.29至8.13]）。
结论：根据GLIM标准的营养不良在CKD患者中非常普遍，并与等待名单上第一年的住院风险增加3倍相关；这些关联在调整年龄后仍然很重要，脆弱状态，握力,和合并症。本文受版权保护。保留所有权利。
