This was a post hoc analysis of 368 patients with advanced CKD. The main study variables were malnutrition, according to the GLIM criteria; number of hospital admissions during the first year on the waiting list; and mortality at the end of follow-up. Kaplan-Meier survival curves and binary logistic regression were performed, adjusting for age, frailty status, handgrip strength, and Charlson Index as potential confounders.
The prevalence of malnutrition was 32.6%. Malnutrition was associated with increased risk of hospitalizations during the first year on the waiting list (odds ratio [OR] = 3.33 [95% CI = 1.34-8.26]), which persisted after adjustment for age and frailty status (adjusted OR = 3.61 [95% CI = 1.38-10.7]), age and handgrip strength (adjusted OR = 3.39 [95% CI = 1.3-8.85]), and age and Charlson Index (adjusted OR = 3.25 [95% CI = 1.29-8.13]).
Malnutrition according to the GLIM criteria was highly prevalent in patients with CKD and was associated with a threefold increased risk of hospitalizations during the first year on the waiting list; these associations remained significant after adjusting for age, frailty status, handgrip strength, and comorbidities.
方法:对368例晚期CKD患者进行事后分析。根据GLIM标准,主要研究变量为营养不良,等待名单上第一年的住院人数,以及随访结束时的死亡率。进行Kaplan-Meier存活曲线和二元逻辑回归,调整年龄,脆弱状态,握力,和Charlson指数作为潜在的混杂因素。
结果:营养不良的患病率为32.6%。营养不良与等待名单第一年住院风险增加相关(OR=3.33[95CI1.34至8.26]),在调整年龄和虚弱状态后仍然存在(调整后的OR=3.61[95CI1.38至10.7]),年龄和握力(调整后的OR=3.39[95CI1.3至8.85]),以及年龄和Charlson指数(调整后的OR=3.25[95CI1.29至8.13])。
结论:根据GLIM标准的营养不良在CKD患者中非常普遍,并与等待名单上第一年的住院风险增加3倍相关;这些关联在调整年龄后仍然很重要,脆弱状态,握力,和合并症。本文受版权保护。保留所有权利。