This study enrolled 113 early stage FEVR patients and 55 age-matched normal subjects. FEVR patients were divided into IRL group and non-IRL group based on the presence or absence of IRL in fovea. The angle of superior temporal and inferior temporal branch retinal arteries on ultra-wide-field fundus images were measured. Superficial and deep vessel density of whole image, fovea and parafovea, the area and perimeter of FAZ, A-circularity index (AI, perimeter/standard circle perimeter with equal area) and vessel density around the 300-μm width of the FAZ (FD), central macular thickness (CMT) on 3 mm × 3mm OCTA were measured.
30 FEVR patients in IRL group, 83 FEVR patients in non-IRL group, 55 normal people in control group were evaluated. BCVA were worst in IRL group (p < .001). The angle of retinal arteries was smaller in FEVR groups (p < .001) and were smallest in IRL group (p < .001). Superficial and deep vessel density of whole and parafovea area in FEVR patients were significantly lower than that in normal people (p < .05), AI were biggest (p = .01) and FD were smallest in IRL group (p < .001). CMT in IRL group were thicker than non-IRL group and control group (p < .05).
Worse BCVA, smaller angle of retinal arteries (more vessels traction), lower macular vessel density, smaller and more irregular FAZ and thicker CMT were observed in FEVR patients with IRL persistence even in early stage.
■这项研究招募了113名早期FEVR患者和55名年龄匹配的正常受试者。根据中央凹有无IRL分为IRL组和非IRL组。在超宽视野眼底图像上测量视网膜颞上和颞下分支动脉的角度。整个图像的浅层和深层血管密度,中央凹和半凹,FAZ的面积和周长,A-圆度指数(AI,周长/等面积的标准圆周长)和FAZ(FD)宽度300μm左右的血管密度,在3mm×3mmOCTA上测量黄斑中心厚度(CMT)。
■IRL组30名FEVR患者,非IRL组83名FEVR患者,对照组55名正常人进行评定。IRL组BCVA最差(p<.001)。FEVR组视网膜动脉角度较小(p<.001),IRL组最小(p<.001)。FEVR患者的整个和旁瓣区的浅表和深层血管密度明显低于正常人群(p<0.05)。IRL组AI最大(p=0.01),FD最小(p<.001)。IRL组CMT高于非IRL组和对照组(p<0.05)。
■更糟糕的BCVA,视网膜动脉的角度较小(更多的血管牵引),黄斑血管密度较低,在IRL持续存在的FEVR患者中观察到更小、更不规则的FAZ和更厚的CMT,即使在早期.