Abstract：
The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.
摘要：
在临床和法医环境中，毒理学分析中替代基质的使用正在增加。口服液（OF），作为非侵入性液体，在药物筛选领域引起了人们的关注，用于治疗和法医目的，以及医学诊断，临床管理，现场（实时）掺杂和监测环境暴露于有毒物质。对于药物浓度,现在建立了OF和血液之间的良好相关性。因此,OF可能是血液的潜在替代品，特别是对于长期监测(例如，治疗药物)或筛查大量患者，以及唾液护理点技术的发展。在这次审查中,我们的目的是总结和批判性地评估当前的文献，这些文献集中在OF和血液标本中药物检测的比较。
