{Reference Type}: Journal Article
{Title}: Recent advances of drugs monitoring in oral fluid and comparison with blood.
{Author}: Casati S;Binda M;Dongiovanni P;Meroni M;D'Amato A;Roda G;Orioli M;Del Fabbro M;Tartaglia GM;
{Journal}: Clin Chem Lab Med
{Volume}: 61
{Issue}: 11
{Year}: 2023 10 26
{Factor}: 8.49
{DOI}: 10.1515/cclm-2023-0343
{Abstract}: The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.