%0 Journal Article
%T Recent advances of drugs monitoring in oral fluid and comparison with blood.
%A Casati S
%A Binda M
%A Dongiovanni P
%A Meroni M
%A D'Amato A
%A Roda G
%A Orioli M
%A Del Fabbro M
%A Tartaglia GM
%J Clin Chem Lab Med
%V 61
%N 11
%D 2023 10 26
%M 37302088
%F 8.49
%R 10.1515/cclm-2023-0343
%X The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.