PDF(Pubmed)
Abstract：
Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients\' daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts\' enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD\'s burden of disease has an impact on patients\' quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out.
摘要：
常染色体多囊肾病是最常见的遗传性肾病，占所有终末期肾病的5%。唯一被批准用于这种情况的疗法是托伐普坦，which,有了它的防水效果，对患者的日常生活有很强的影响。最近,通过分析减缓囊肿增大和慢性肾脏病进展的可能的非药物治疗策略的新工作,丰富了文献.其中,在一些临床前和临床研究中，已经证明减少碳水化合物摄入和诱导酮症的饮食方案具有功效。生酮饮食，卡路里限制,间歇性禁食,而限时进食可以减少有氧糖酵解并抑制mTOR通路，导致囊肿细胞增殖减少，肾脏体积的减少，有助于保护肾功能。ADPKD的疾病负担对患者的生活质量有影响，运动或进行体育锻炼的可能性可以帮助人们在日常生活中。这种疾病的多系统特征，尤其是心血管受累,需要仔细评估，以确定患者可以安全进行的身体活动的质量和数量。
