Abstract：
Acetone presence in human biological specimens can result from exogenous administration or endogenous production, resulting from diabetes, dietary composition, alcoholism, and stress response. Victims of drug-facilitated sexual assaults (DFSA) are understood to experience enhanced stress. At the Harris County Institute of Forensic Sciences (HCIFS), DFSA drug testing includes analysis of volatile compounds, ethanol, methanol, isopropanol, and acetone, by headspace gas chromatography/flame ionization detection. The prevalence of acetone-positive specimens in DFSA casework has been observed to exceed that of other human performance case types. In this report, DFSA cases received between 2019 and 2021 (n = 393) were reviewed and 41 acetone-positive cases were detailed. Overall, nearly 11% of the DFSA cases had acetone-positive blood or urine specimens, where 3% identified acetone only, 6% identified acetone and other drug(s), and 2% identified acetone, ethanol, and other drug(s). Acetone concentrations ranged from 0.010 to 0.147 g/100 mL in urine. Other drugs such as nor-carboxy-Δ9 -tetrahydrocannabinol, amphetamine, methamphetamine, ethanol, and benzoylecgonine were commonly detected. Elevated stress response encountered during DFSAs may facilitate the mechanism behind enhanced acetone production leading to increased identification. Limited availability of victim medical history precludes understanding the contribution of other disease states or physiological conditions. Nonetheless, the identification of acetone in DFSA specimens supports its potential as a biomarker of trauma in forensic toxicology casework and warrants future research within the community.
摘要：
人生物标本中丙酮的存在可由外源性给药或内源性产生，由于糖尿病，膳食组成，酗酒,和应激反应。药物促进的性侵犯（DFSA）的受害者被理解为承受更大的压力。在哈里斯县法医学研究所（HCIFS），DFSA药物测试包括挥发性化合物的分析，乙醇,甲醇,异丙醇,还有丙酮,通过顶空气相色谱/火焰离子化检测。已观察到DFSA病例中丙酮阳性标本的患病率超过其他人类表现病例类型。在这份报告中,审查了2019年至2021年收到的DFSA病例（n=393），并详细介绍了41例丙酮阳性病例。总的来说,近11%的DFSA病例有丙酮阳性的血液或尿液标本，只有3%的人确定了丙酮，6%确定丙酮和其他药物，和2%确定的丙酮，乙醇,和其他药物。尿液中的丙酮浓度范围为0.010至0.147g/100mL。其他药物，如nor-羧基-Δ9-四氢大麻酚，安非他明,甲基苯丙胺,乙醇,和苯甲酰基芽子碱是常见的检测。在DFSA期间遇到的升高的应激反应可以促进丙酮产生增强导致鉴定增加的背后的机制。受害者病史的有限可用性妨碍了理解其他疾病状态或生理状况的贡献。尽管如此，DFSA标本中丙酮的鉴定支持了其作为法医毒理学案例中创伤生物标志物的潜力,并有必要在社区内进行未来的研究.
