PDF(Pubmed)
Abstract：
Coronavirus pandemic has been a huge jeopardy to human health in various systems since it outbroke, early detection and prevention of further escalation has become a priority. The current popular approach is to collect samples using the nasopharyngeal swab method and then test for RNA using the real-time polymerase chain reaction, which suffers from false-positive results and a longer diagnostic time scale. Alternatively, various optical techniques, namely, optical sensing, spectroscopy, and imaging shows a great promise in virus detection. In this mini review, we briefly summarize the development progress of vibrational spectroscopy techniques and its applications in the detection of SARS-CoV family. Vibrational spectroscopy techniques such as Raman spectroscopy and infrared spectroscopy received increasing appreciation in bio-analysis for their speediness, accuracy and cost-effectiveness in detection of SARS-CoV. Further, an account of emerging photonics technologies of SARS-CoV-2 detection and future possibilities is also explained. The progress in the field of vibrational spectroscopy techniques for virus detection unambiguously show a great promise in the development of rapid photonics-based devices for COVID-19 detection.
摘要：
冠状病毒大流行自爆发以来，在各个系统中对人类健康构成了巨大威胁，及早发现和防止进一步升级已成为当务之急。目前流行的方法是用鼻咽拭子法采集样本,然后用实时聚合酶链反应检测RNA,其遭受假阳性结果和更长的诊断时间尺度。或者，各种光学技术，即,光学传感,光谱学,成像在病毒检测中显示出巨大的前景。在这个迷你评论中，简要综述了振动光谱技术的研究进展及其在SARS-CoV家族检测中的应用。振动光谱技术如拉曼光谱和红外光谱在生物分析方面因其速度而受到越来越多的赞赏，SARS-CoV检测的准确性和成本效益。Further,还解释了SARS-CoV-2检测的新兴光子学技术以及未来的可能性。病毒检测振动光谱技术领域的进展无疑在开发基于光子学的快速COVID-19检测设备方面显示出巨大的前景。
