METHODS: This retrospective study involved 55 patients with early local recurrent GSCC treated with TLM, and the oncologic outcomes, functional outcomes, hospitalization time and complications were compared with a group of 40 recurrent GSCC patients matched for clinical variables of TLM group, treated by OPL by the same team of surgeons.
RESULTS: The 5-year overall survival and disease-specific survival rates were 65.8% and 91.5%, respectively, for 55 patients with rTis-rT2 stage treated by TLM and 77.1% and 94.7%, respectively, for 40 patients with rTis-rT2 stage treated by OPL (OPL group). In the TLM and OPL groups, the local control rates after 5 years were 77.5% and 79.3%, respectively, and the laryngeal preservation rates were 94.4% and 83.6%, respectively (p > 0.05). Compared with the OPL group, the complication rate (1.82%) and hospitalization duration (5.42 ± 2.26 days) were significantly lower in the TLM group (p < 0.05). Compared with the OPL group, postsurgical health-related quality of life and quality of voice were significantly better in the TLM group (p < 0.001).
CONCLUSIONS: Salvage TLM can be used as an effective treatment option for suitable patients after a full, comprehensive, and careful assessment of the characteristics of early locally recurrent glottic carcinoma.
方法:本回顾性研究纳入55例早期局部复发GSCC患者,和肿瘤的结果,功能结果,将住院时间和并发症与TLM组的40例复发GSCC患者进行比较,由OPL由同一外科医生团队治疗。
结果:5年总生存率和疾病特异性生存率分别为65.8%和91.5%,分别,对于55例接受TLM治疗的rTis-rT2期患者,分别为77.1%和94.7%,分别,对于40例接受OPL治疗的rTis-rT2期患者(OPL组)。在TLM和OPL组中,5年后的局部控制率分别为77.5%和79.3%,分别,喉保存率分别为94.4%和83.6%,分别为(p>0.05)。与OPL组相比,TLM组的并发症发生率(1.82%)和住院时间(5.42±2.26天)明显低于TLM组(p<0.05)。与OPL组相比,TLM组术后健康相关生活质量和嗓音质量显著改善(p<0.001).
结论:打捞TLM可以作为一种有效的治疗选择,适合患者经过充分的治疗,全面,并仔细评估早期局部复发性声门癌的特征。