PDF(Pubmed)
Abstract：
The maintenance of a high delivery efficiency by traditional nanomedicines during cancer treatment is a challenging task. As a natural mediator for short-distance intercellular communication, extracellular vesicles (EVs) have garnered significant attention owing to their low immunogenicity and high targeting ability. They can load a variety of major drugs, thus offering immense potential. In order to overcome the limitations of EVs and establish them as an ideal drug delivery system, polymer-engineered extracellular vesicle mimics (EVMs) have been developed and applied in cancer therapy. In this review, we discuss the current status of polymer-based extracellular vesicle mimics in drug delivery, and analyze their structural and functional properties based on the design of an ideal drug carrier. We anticipate that this review will facilitate a deeper understanding of the extracellular vesicular mimetic drug delivery system, and stimulate the progress and advancement of this field.
摘要：
在癌症治疗期间通过传统纳米药物维持高递送效率是具有挑战性的任务。作为短距离细胞间通信的自然中介，细胞外囊泡（EV）由于其低免疫原性和高靶向能力而受到广泛关注。他们可以装载各种主要药物，从而提供了巨大的潜力。为了克服电动汽车的局限性，建立电动汽车作为理想的给药系统，聚合物工程化的细胞外囊泡模拟物（EVM）已被开发并应用于癌症治疗。在这次审查中,我们讨论了基于聚合物的细胞外囊泡模拟物在药物递送中的现状，并在设计理想药物载体的基础上分析其结构和功能特性。我们预计，这篇综述将有助于更深入地了解细胞外囊泡模拟药物递送系统，并促进这一领域的进步和进步。
