{Reference Type}: Journal Article
{Title}: Polymers in Engineering Extracellular Vesicle Mimetics: Current Status and Prospective.
{Author}: Wei X;Liu S;Cao Y;Wang Z;Chen S;
{Journal}: Pharmaceutics
{Volume}: 15
{Issue}: 5
{Year}: 2023 May 14
{Factor}: 6.525
{DOI}: 10.3390/pharmaceutics15051496
{Abstract}: The maintenance of a high delivery efficiency by traditional nanomedicines during cancer treatment is a challenging task. As a natural mediator for short-distance intercellular communication, extracellular vesicles (EVs) have garnered significant attention owing to their low immunogenicity and high targeting ability. They can load a variety of major drugs, thus offering immense potential. In order to overcome the limitations of EVs and establish them as an ideal drug delivery system, polymer-engineered extracellular vesicle mimics (EVMs) have been developed and applied in cancer therapy. In this review, we discuss the current status of polymer-based extracellular vesicle mimics in drug delivery, and analyze their structural and functional properties based on the design of an ideal drug carrier. We anticipate that this review will facilitate a deeper understanding of the extracellular vesicular mimetic drug delivery system, and stimulate the progress and advancement of this field.