Abstract：
Clozapine was first manufactured in China in 1976. Clozapine is currently used not only for treatment-refractory schizophrenia (TRS), but also continues to be used in the treatment of patients with non-TRS and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic therapy and in combination with other drugs. There is need for studies in China using various titrations and assessing their risk for myocarditis and aspiration pneumonia. The Chinese clozapine package insert will also greatly benefit from these changes.
摘要：
氯氮平于1976年在中国首次生产。氯氮平目前不仅用于治疗难治性精神分裂症（TRS），但也继续用于治疗非TRS和其他精神障碍患者;此外，低剂量氯氮平也用于镇静催眠治疗以及与其他药物联合使用。在中国，有必要使用各种滴定法进行研究，并评估其心肌炎和吸入性肺炎的风险。中国氯氮平包装说明书也将大大受益于这些变化。
