%0 Journal Article
%T A brief history of clozapine in China with a look forward.
%A Ruan CJ
%A Wang CY
%A Zang YN
%A Liu CG
%A Dong F
%A Li AN
%A Wan Z
%A Guo W
%A Wang G
%J Schizophr Res
%V 268
%N 0
%D 2024 Jun 24
%M 37236890
%F 4.662
%R 10.1016/j.schres.2023.03.048
%X Clozapine was first manufactured in China in 1976. Clozapine is currently used not only for treatment-refractory schizophrenia (TRS), but also continues to be used in the treatment of patients with non-TRS and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic therapy and in combination with other drugs. There is need for studies in China using various titrations and assessing their risk for myocarditis and aspiration pneumonia. The Chinese clozapine package insert will also greatly benefit from these changes.