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Abstract：
The use of specific inhibitory drugs of intracellular signalling pathways (such as Bruton-Kinase inhibitors) for the treatment of Waldenström\'s macroglobulinaemia (WM) is a recognised risk factor for Aspergillus spp. infections. The overlapping clinical manifestations of the two diseases may require the involvement of different medical specialities. We describe the clinical course of a patient with pulmonary and encephalic aspergillosis, with concomitant orbital infiltration, which represented a difficult diagnosis: the case required a multidisciplinary approach to define the ocular lesions and an in-depth study of the literature.
摘要：
使用细胞内信号通路的特异性抑制药物（例如布鲁顿激酶抑制剂）治疗Waldenström巨球蛋白血症（WM）是公认的曲霉属的危险因素。感染。两种疾病的重叠临床表现可能需要不同医学专业的参与。我们描述了肺和脑曲霉病患者的临床过程，伴随着眼眶浸润，这代表了一个困难的诊断：该病例需要多学科的方法来定义眼部病变，并对文献进行深入研究。
