PDF(Pubmed)
Abstract：
The process of epithelial-to-mesenchymal transition (EMT) is crucial in the implantation of the blastocyst and subsequent placental development. The trophoblast, consisting of villous and extravillous zones, plays different roles in these processes. Pathological states, such as placenta accreta spectrum (PAS), can arise due to dysfunction of the trophoblast or defective decidualization, leading to maternal and fetal morbidity and mortality. Studies have drawn parallels between placentation and carcinogenesis, with both processes involving EMT and the establishment of a microenvironment that facilitates invasion and infiltration. This article presents a review of molecular biomarkers involved in both the microenvironment of tumors and placental cells, including placental growth factor (PlGF), vascular endothelial growth factor (VEGF), E-cadherin (CDH1), laminin γ2 (LAMC2), the zinc finger E-box-binding homeobox (ZEB) proteins, αVβ3 integrin, transforming growth factor β (TGF-β), β-catenin, cofilin-1 (CFL-1), and interleukin-35 (IL-35). Understanding the similarities and differences in these processes may provide insights into the development of therapeutic options for both PAS and metastatic cancer.
摘要：
上皮-间质转化（EMT）的过程在胚泡的植入和随后的胎盘发育中至关重要。滋养细胞,由绒毛和杂乱区组成，在这些过程中扮演不同的角色。病理状态,如胎盘植入谱(PAS)，可能是由于滋养层细胞功能障碍或蜕膜化缺陷引起的，导致孕产妇和胎儿的发病率和死亡率。研究已经得出了胎盘形成和致癌作用之间的相似之处，这两个过程都涉及EMT和建立促进入侵和渗透的微环境。本文对涉及肿瘤微环境和胎盘细胞的分子生物标志物进行了综述。包括胎盘生长因子（PlGF），血管内皮生长因子（VEGF），E-钙黏着蛋白（CDH1），层粘连蛋白γ2（LAMC2），锌指E盒结合同源异型盒(ZEB)蛋白，αVβ3整合素,转化生长因子β（TGF-β），β-连环蛋白，cofilin-1(CFL-1)，和白细胞介素-35(IL-35)。了解这些过程的相似性和差异可以为PAS和转移性癌症的治疗选择的发展提供见解。
