Abstract：
Nucleic acid nanotechnology provides the ability to create unprecedented nanostructures with diverse architectures and functions that can be utilized in myriad fields. A set of self-folding, single-stranded RNA origami structures bearing thrombin RNA aptamers have been demonstrated to act as anticoagulants. Here, we describe the detailed methods of producing and testing of such RNA origami anticoagulants. This method highlights the potential of RNA origami for biomedical applications.
摘要：
核酸纳米技术提供了创造前所未有的纳米结构的能力，具有不同的架构和功能，可用于无数领域。一套自折叠，携带凝血酶RNA适体的单链RNA折纸结构已被证明可作为抗凝剂。这里,我们描述了生产和测试这种RNA折纸抗凝剂的详细方法。这种方法突出了RNA折纸在生物医学应用中的潜力。
