PDF(Pubmed)
Abstract：
Chronic cough (cough that persists for ≥ 8 weeks) can cause a range of physical symptoms and psychosocial effects that significantly impair patients\' quality of life. Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are challenging to diagnose and manage, with substantial economic implications for healthcare systems.
This retrospective multicenter non-interventional study aimed to characterize the profile and health resource consumption of patients with RCC or UCC who attended outpatient clinics at Spanish hospitals. Data were collected from medical records of patients with RCC or UCC for up to 3 years before study inclusion.
The patient cohort (n = 196) was representative of the chronic cough population (77.6% female, mean age 58.5 years). Two-thirds of patients (n = 126) had RCC. The most frequently visited doctors were pulmonologists (93.4% of patients) and primary care physicians (78.6%), with a mean of 5 visits per patient over three years\' observation. The most common diagnostic tests were chest x-ray (83.7%) and spirometry with bronchodilation (77.0%). The most commonly prescribed treatments were proton pump inhibitors (79.6%) and respiratory medications (87.8%). Antibiotics were prescribed empirically to 56 (28.6%) patients. Differences between RCC or UCC groups related mainly to approaches used to manage cough-associated conditions (gastroesophageal reflux disease, asthma) in patients with RCC.
RCC and UCC are responsible for high health resource utilization in Spanish hospitals. Specific treatments targeting the pathological processes driving chronic cough may provide opportunities to reduce the associated burden for patients and healthcare systems.
This retrospective multicenter non-interventional study aimed to characterize the profile and health resource consumption of patients with RCC or UCC who attended outpatient clinics at Spanish hospitals. Data were collected from medical records of patients with RCC or UCC for up to 3 years before study inclusion.
The patient cohort (n = 196) was representative of the chronic cough population (77.6% female, mean age 58.5 years). Two-thirds of patients (n = 126) had RCC. The most frequently visited doctors were pulmonologists (93.4% of patients) and primary care physicians (78.6%), with a mean of 5 visits per patient over three years\' observation. The most common diagnostic tests were chest x-ray (83.7%) and spirometry with bronchodilation (77.0%). The most commonly prescribed treatments were proton pump inhibitors (79.6%) and respiratory medications (87.8%). Antibiotics were prescribed empirically to 56 (28.6%) patients. Differences between RCC or UCC groups related mainly to approaches used to manage cough-associated conditions (gastroesophageal reflux disease, asthma) in patients with RCC.
RCC and UCC are responsible for high health resource utilization in Spanish hospitals. Specific treatments targeting the pathological processes driving chronic cough may provide opportunities to reduce the associated burden for patients and healthcare systems.
摘要：
目的：慢性咳嗽（咳嗽持续≥8周）可引起一系列躯体症状和心理社会效应，显著损害患者的生活质量。难治性慢性咳嗽（RCC）和原因不明的慢性咳嗽（UCC）是具有挑战性的诊断和管理，对医疗保健系统具有重大的经济影响。
方法：这项回顾性多中心非干预性研究旨在描述在西班牙医院门诊就诊的RCC或UCC患者的特征和健康资源消耗。在纳入研究之前，从RCC或UCC患者的病历中收集数据长达3年。
结果：患者队列（n=196）代表慢性咳嗽人群（77.6%为女性，平均年龄58.5岁)。三分之二的患者（n=126）患有RCC。就诊频率最高的医生是肺科医师(93.4%的病人)和初级保健医师(78.6%),在三年的观察中，每位患者平均5次就诊。最常见的诊断测试是胸部X光检查（83.7％）和支气管扩张肺活量测定（77.0％）。最常见的处方治疗是质子泵抑制剂（79.6％）和呼吸药物（87.8％）。对56名(28.6%)患者进行了经验性的抗生素处方。RCC或UCC组之间的差异主要与用于治疗咳嗽相关疾病的方法有关（胃食管反流病，RCC患者的哮喘）。
结论：RCC和UCC是西班牙医院卫生资源利用率高的原因。针对驱动慢性咳嗽的病理过程的特定治疗可以提供减少患者和医疗保健系统的相关负担的机会。
方法：这项回顾性多中心非干预性研究旨在描述在西班牙医院门诊就诊的RCC或UCC患者的特征和健康资源消耗。在纳入研究之前，从RCC或UCC患者的病历中收集数据长达3年。
结果：患者队列（n=196）代表慢性咳嗽人群（77.6%为女性，平均年龄58.5岁)。三分之二的患者（n=126）患有RCC。就诊频率最高的医生是肺科医师(93.4%的病人)和初级保健医师(78.6%),在三年的观察中，每位患者平均5次就诊。最常见的诊断测试是胸部X光检查（83.7％）和支气管扩张肺活量测定（77.0％）。最常见的处方治疗是质子泵抑制剂（79.6％）和呼吸药物（87.8％）。对56名(28.6%)患者进行了经验性的抗生素处方。RCC或UCC组之间的差异主要与用于治疗咳嗽相关疾病的方法有关（胃食管反流病，RCC患者的哮喘）。
结论：RCC和UCC是西班牙医院卫生资源利用率高的原因。针对驱动慢性咳嗽的病理过程的特定治疗可以提供减少患者和医疗保健系统的相关负担的机会。
