PDF(Pubmed)
Abstract：
With an aging population, cognitive decline and neurodegenerative disorders are an emerging public health crises with enormous, yet still under-recognized burdens. Alzheimer\'s disease (AD) is the most common type of dementia, and the number of cases is expected to dramatically rise in the upcoming decades. Substantial efforts have been placed into understanding the disease. One of the primary avenues of research is neuroimaging, and while positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are most common, crucial recent advancements in electrophysiological methods such as magnetoencephalography (MEG) and electroencephalography (EEG) have provided novel insight into the aberrant neural dynamics at play in AD pathology. In this review, we outline task-based M/EEG studies published since 2010 using paradigms probing the cognitive domains most affected by AD, including memory, attention, and executive functioning. Furthermore, we provide important recommendations for adapting cognitive tasks for optimal use in this population and adjusting recruitment efforts to improve and expand future neuroimaging work.
摘要：
随着人口老龄化,认知功能下降和神经退行性疾病是新出现的公共卫生危机,但仍有巨大的负担.阿尔茨海默病(AD)是最常见的痴呆类型,病例数量预计将在未来几十年急剧上升。已经做出了大量努力来了解这种疾病。研究的主要途径之一是神经成像，而正电子发射断层扫描（PET）和功能磁共振成像（fMRI）是最常见的，脑磁图（MEG）和脑电图（EEG）等电生理学方法的最新进展为AD病理学中的异常神经动力学提供了新的见解。在这次审查中,我们概述了自2010年以来发表的基于任务的M/EEG研究，使用范式探测受AD影响最大的认知领域，包括记忆，注意,和执行功能。此外，我们为调整认知任务以在该人群中最佳使用以及调整招募工作以改善和扩大未来的神经影像学工作提供了重要建议.
