Abstract：
Histiocytic, dendritic, and stromal cell lesions that occur in the spleen are challenging diagnostically, not well studied due to their rarity, and therefore somewhat controversial. New techniques for obtaining tissue samples also create challenges as splenectomy is no longer common and needle biopsy does not afford the same opportunity for examination of tissue. Characteristic primary splenic histiocytic, dendritic, and stromal cell lesions are presented in this paper with new molecular genetic findings in some entities that help differentiate these lesions from those occurring in non-splenic sites, such as soft tissue, and identify possible molecular markers for diagnosis.
摘要：
组织细胞,树突状,脾脏中发生的基质细胞病变在诊断上具有挑战性，由于它们的稀有性，没有得到很好的研究，因此有些争议。用于获得组织样本的新技术也带来了挑战,因为脾切除术不再常见,并且针吸活检不能提供相同的组织检查机会。特征性原发性脾组织细胞，树突状,和基质细胞病变在本文中提出了一些实体的新分子遗传学发现，有助于区分这些病变与非脾部位发生的病变，比如软组织，并确定可能的分子标记用于诊断。
