■Faidherbiaalbida,在豪萨俗称gawo,传统上用于治疗Kebbi州祖鲁酋长国的黄疸。在这里,在Wistar白化病大鼠中研究了F.albida对2.4-二硝基苯肼诱导的高胆红素血症的改善作用。
■30只健康大鼠给药75mg的2.4-二硝基苯肼以诱导高胆红素血症。此后,第1-3组接受500、750和1000mg/kg体重的甲醇树皮提取物,第4组给予苯巴比妥15mg/kg(标准药物)。第5组和第6组作为未治疗和正常对照,分别。使用标准方法评估植物化学成分,和急性口服毒性使用OECD2008年标准指南进行评估。
■植物化学分析显示生物碱的存在,酚类物质,和大量的单宁。直接胆红素显著降低(P<0.05),总胆红素,观察到所有剂量的提取物和标准药物与未处理组相比的总蛋白水平。同样,血清天冬氨酸氨基转移酶(AST)显着降低,丙氨酸氨基转移酶(ALT),和碱性磷酸酶(ALP)水平与在未处理的对照中观察到的升高的水平相比,用标准药物处理的组和所有提取物处理的组。然而,血清白蛋白(ALB)水平显着增加(P<0.05),红细胞,血红蛋白,与未处理组相比,在所有提取物处理的对照中观察到细胞体积和包装体积,而与未处理组相比,处理组中MCH水平显著降低。
■F.albida改善了Wistar白化病大鼠中2.4-二硝基苯肼引起的高胆红素血症,从而为其在传统医学中的应用提供一定的支持。
UNASSIGNED: Faidherbia albida, popularly known as gawo in Hausa, is traditionally used to treat jaundice in Zuru emirate of Kebbi State. Herein, the ameliorative effect of F. albida against 2.4-dinitrophenylhydrazine-induced hyperbilirubinemia in Wistar albino rats was investigated.
UNASSIGNED: Thirty healthy rats were administered 75 mg of 2.4-dinitrophenylhydrazine to induce hyperbilirubinemia. Thereafter, groups 1-3 received 500, 750, and 1000 mg/kg body weight of the methanol stem-bark extract, and 15 mg/kg of phenobarbitone (standard drug) was administered to group 4. Groups 5 and 6 served as the untreated and normal controls, respectively. The phytochemical composition was evaluated using standard methods, and acute oral toxicity was evaluated using standard OECD 2008 guidelines.
UNASSIGNED: Phytochemical analysis revealed the presence of alkaloids, phenols, and a substantial amount of tannins. A significant (P<0.05) reduction of direct bilirubin, total bilirubin, and total protein levels for all the doses of the extract and standard drug compared to untreated groups was observed. Similarly, there were significant reductions in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels of the group treated with the standard drug and all extract-treated groups compared to elevated levels observed in untreated controls. However, a significant (P<0.05) increase in serum albumin (ALB) levels, red blood cells, hemoglobin, and pack cell volume was observed in all extract-treated compared to the untreated control in contrast to a significant decrease in MCH levels in treated groups compared to the untreated group.
UNASSIGNED: F. albida ameliorated the hyperbilirubinemia induced by 2.4-dinitrophenylhydrazine in Wistar albino rats, thus providing some support for its use in traditional medicine to treat jaundice.