Abstract：
We conducted a two-year inhalation study of butyl methacrylate using F344/DuCrlCrlj rats and B6D2F1/Crl mice. Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavities of both rats and mice, but neoplastic lesions were not found. There was also a positive trend in the incidence of large granular lymphocytic (LGL) leukemia in the spleen of male rats. No changes were observed in female rats. Overall, there is some evidence of carcinogenicity in male rats, but there is no evidence of carcinogenicity in female rats. In male mice, there was a positive trend by Peto\'s test in the incidence of hepatocellular adenomas, and the incidence of hepatocellular adenomas and hepatocellular carcinomas combined was significantly increased compared to the controls by Fisher\'s exact test in the 30 ppm exposed male group. In female mice, the incidence of hemangiosarcoma in all organs combined showed a positive trend by Peto\'s test. Therefore, there is some evidence of carcinogenicity in male mice, and there is equivocal evidence of carcinogenicity in female mice.
摘要：
我们使用F344/DuCrlCrlj大鼠和B6D2F1/Crl小鼠进行了为期两年的甲基丙烯酸丁酯吸入研究。将大鼠暴露于0、30、125和500ppm(v/v),并使用全身吸入室将小鼠暴露于0、8、30和125ppm(v/v)。大鼠和小鼠的鼻腔均出现非肿瘤性病变，但未发现肿瘤性病变。雄性大鼠脾脏中大颗粒淋巴细胞（LGL）白血病的发生率也呈正趋势。在雌性大鼠中没有观察到变化。总的来说,有一些证据表明雄性大鼠有致癌性，但是没有证据表明雌性大鼠有致癌性。在雄性小鼠中,有一个积极的趋势通过Peto的测试在肝细胞腺瘤的发病率，在30ppm暴露的男性组中，通过Fisher精确检验，与对照组相比，肝细胞腺瘤和肝细胞癌的发生率显着增加。在雌性老鼠中，通过Peto检验，所有器官中血管肉瘤的发生率均呈阳性趋势。因此,在雄性小鼠中有一些致癌性的证据，而且在雌性小鼠中也有明确的致癌性证据.
