PDF(Pubmed)
Abstract：
The posterior-to-anterior shift in aging (PASA) effect is seen as a compensatory model that enables older adults to meet increased cognitive demands to perform comparably as their young counterparts. However, empirical support for the PASA effect investigating age-related changes in the inferior frontal gyrus (IFG), hippocampus, and parahippocampus has yet to be established. 33 older adults and 48 young adults were administered tasks sensitive to novelty and relational processing of indoor/outdoor scenes in a 3-Tesla MRI scanner. Functional activation and connectivity analyses were applied to examine the age-related changes on the IFG, hippocampus, and parahippocampus among low/high-performing older adults and young adults. Significant parahippocampal activation was generally found in both older (high-performing) and young adults for novelty and relational processing of scenes. Younger adults had significantly greater IFG and parahippocampal activation than older adults, and greater parahippocampal activation compared to low-performing older adults for relational processing-providing partial support for the PASA model. Observations of significant functional connectivity within the medial temporal lobe and greater negative left IFG-right hippocampus/parahippocampus functional connectivity for young compared to low-performing older adults for relational processing also supports the PASA effect partially.
摘要：
老化的后前移（PASA）效应被视为一种代偿模型，使老年人能够满足增加的认知需求，与年轻的同龄人表现相当。然而,对PASA效应调查额下回（IFG）与年龄相关的变化的经验支持，海马体,海马旁尚未建立。在3特斯拉MRI扫描仪中，对33名老年人和48名年轻人进行了对室内/室外场景的新颖性和关系处理敏感的任务。功能性激活和连通性分析用于检查IFG上与年龄相关的变化，海马体,低/高表现的老年人和年轻人的海马旁。对于新颖性和场景的关系处理，通常在老年人（高性能）和年轻人中都发现了明显的海马旁激活。年轻人的IFG和海马旁激活明显高于老年人，与表现不佳的老年人相比，海马旁激活更大，以进行关系处理-为PASA模型提供部分支持。与低表现的老年人相比，年轻人在内侧颞叶内的显着功能连接和更大的负左IFG-右海马/海马旁功能连接的观察也部分支持了PASA效应。
