PDF(Pubmed)
Abstract：
Infections caused by multidrug-resistant Acinetobacter baumannii (MDR-Ab) have become a public health emergency. Due to the small therapeutic arsenal available to treat these infections, health agencies have highlighted the importance of developing new antimicrobials against MDR-Ab. In this context, antimicrobial peptides (AMPs) stand out, and animal venoms are a rich source of these compounds. Here, we aimed to summarize the current knowledge on the use of animal venom-derived AMPs in the treatment of MDR-Ab infections in vivo. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The eight studies included in this review identified the antibacterial activity of eleven different AMPs against MDR-Ab. Most of the studied AMPs originated from arthropod venoms. In addition, all AMPs are positively charged and rich in lysine residues. In vivo assays showed that the use of these compounds reduces MDR-Ab-induced lethality and bacterial load in invasive (bacteremia and pneumonia) and superficial (wounds) infection models. Moreover, animal venom-derived AMPs have pleiotropic effects, such as pro-healing, anti-inflammatory, and antioxidant activities, that help treat infections. Animal venom-derived AMPs are a potential source of prototype molecules for the development of new therapeutic agents against MDR-Ab.
摘要：
多重耐药鲍曼不动杆菌(MDR-Ab)感染已成为突发公共卫生事件。由于可用于治疗这些感染的治疗武器库较小，卫生机构强调了开发针对MDR-Ab的新型抗菌药物的重要性.在这种情况下，抗菌肽（AMP）脱颖而出，动物毒液是这些化合物的丰富来源。这里,我们旨在总结目前在体内使用动物毒液衍生的AMPs治疗MDR-Ab感染的知识。根据系统评价和荟萃分析指南的首选报告项目进行系统评价。本综述中包含的8项研究确定了11种不同的AMP对MDR-Ab的抗菌活性。大多数研究的AMP起源于节肢动物的毒液。此外,所有的AMPs都带正电荷并且富含赖氨酸残基。体内试验表明,在侵袭性(菌血症和肺炎)和浅表(伤口)感染模型中,使用这些化合物降低了MDR-Ab诱导的致死性和细菌负荷。此外，动物毒液衍生的AMPs具有多效性，如促愈合，抗炎,和抗氧化活性，有助于治疗感染。动物毒液衍生的AMP是用于开发针对MDR-Ab的新治疗剂的原型分子的潜在来源。
