PDF(Pubmed)
Abstract：
UNASSIGNED: Globally, the incidence of herpes zoster (HZ) is increasing, and the resulting zoster-associated pain (ZAP) severely affects the quality of life of patients. Therefore, active treatment of ZAP and prevention of postherpetic neuralgia (PHN) are very important for patients in the early stage of the disease. This retrospective observational study aimed to evaluate the effect of CT-guided pulsed radiofrequency (PRF) combined with ozone injection on zoster-associated pain.
UNASSIGNED: From 2018 to 2020, 84 patients with AHN (n=28), SHN (n=32), or PHN (n=24) underwent PRF combined with ozone injection treatment after pharmacologic and conservative therapies failed. The visual analogue scale (VAS), the Pittsburgh Sleep Quality Index (PSQI), and pregabalin consumption were recorded at baseline, post-PRF, and at 1, 3, 6, and 12 months after treatment. The number of remediations performed and adverse reactions were recorded, and treatment inefficiency was calculated using a VAS score greater than 3 as the criterion.
UNASSIGNED: The pooled results demonstrated statistically significant decreases in VAS scores, PSQI scores and consumption of pregabalin post-PRF and at 1, 3, 6, and 12 months follow-up (P<0.05). Compared with the PHN group, both the AHN and SHN groups showed clinical and statistical improvement in VAS scores and PSQI scores and in consumption of pregabalin (P< 0.05). At 1 year after the operation, the PHN group had a significantly greater number of remediation events and greater treatment inefficiency than the other two groups. No serious adverse events were observed during the procedure or during the follow-up period.
UNASSIGNED: CT-guided PRF combined with ozone injection is safe and effective for individuals with ZAP, and its short-term and long-term effects are significant. In a sense, early PRF combined with ozone injection is more effective.
UNASSIGNED: From 2018 to 2020, 84 patients with AHN (n=28), SHN (n=32), or PHN (n=24) underwent PRF combined with ozone injection treatment after pharmacologic and conservative therapies failed. The visual analogue scale (VAS), the Pittsburgh Sleep Quality Index (PSQI), and pregabalin consumption were recorded at baseline, post-PRF, and at 1, 3, 6, and 12 months after treatment. The number of remediations performed and adverse reactions were recorded, and treatment inefficiency was calculated using a VAS score greater than 3 as the criterion.
UNASSIGNED: The pooled results demonstrated statistically significant decreases in VAS scores, PSQI scores and consumption of pregabalin post-PRF and at 1, 3, 6, and 12 months follow-up (P<0.05). Compared with the PHN group, both the AHN and SHN groups showed clinical and statistical improvement in VAS scores and PSQI scores and in consumption of pregabalin (P< 0.05). At 1 year after the operation, the PHN group had a significantly greater number of remediation events and greater treatment inefficiency than the other two groups. No serious adverse events were observed during the procedure or during the follow-up period.
UNASSIGNED: CT-guided PRF combined with ozone injection is safe and effective for individuals with ZAP, and its short-term and long-term effects are significant. In a sense, early PRF combined with ozone injection is more effective.
摘要：
■全球，带状疱疹（HZ）的发病率正在增加，和由此产生的带状疱疹相关性疼痛（ZAP）严重影响患者的生活质量。因此,积极治疗ZAP和预防带状疱疹后遗神经痛（PHN）对于疾病早期患者非常重要。这项回顾性观察性研究旨在评估CT引导下脉冲射频（PRF）联合臭氧注射对带状疱疹相关性疼痛的影响。
■从2018年到2020年，84例AHN患者（n=28），SHN（n=32），或PHN（n=24）在药物和保守治疗失败后接受PRF联合臭氧注射治疗。视觉模拟量表(VAS)匹兹堡睡眠质量指数(PSQI)和普瑞巴林的消耗记录在基线，PRF后，治疗后1、3、6和12个月。记录所进行的治疗次数和不良反应,以VAS评分大于3为标准计算治疗无效率.
■汇总结果显示VAS评分有统计学意义的下降，PSQI评分及PRF后1、3、6、12个月的普瑞巴林用量(P<0.05)。与PHN组相比，AHN组和SHN组在VAS评分和PSQI评分以及普瑞巴林的消耗方面均显示出临床和统计学上的改善（P<0.05）。手术后一年，与其他两组相比,PHN组的补救事件显著增多,治疗无效率显著增加.在手术期间或随访期间未观察到严重不良事件。
■CT引导的PRF结合臭氧注射对ZAP患者安全有效，其短期和长期效应都很显著。在某种意义上,早期PRF结合臭氧注入更有效。
■从2018年到2020年，84例AHN患者（n=28），SHN（n=32），或PHN（n=24）在药物和保守治疗失败后接受PRF联合臭氧注射治疗。视觉模拟量表(VAS)匹兹堡睡眠质量指数(PSQI)和普瑞巴林的消耗记录在基线，PRF后，治疗后1、3、6和12个月。记录所进行的治疗次数和不良反应,以VAS评分大于3为标准计算治疗无效率.
■汇总结果显示VAS评分有统计学意义的下降，PSQI评分及PRF后1、3、6、12个月的普瑞巴林用量(P<0.05)。与PHN组相比，AHN组和SHN组在VAS评分和PSQI评分以及普瑞巴林的消耗方面均显示出临床和统计学上的改善（P<0.05）。手术后一年，与其他两组相比,PHN组的补救事件显著增多,治疗无效率显著增加.在手术期间或随访期间未观察到严重不良事件。
■CT引导的PRF结合臭氧注射对ZAP患者安全有效，其短期和长期效应都很显著。在某种意义上,早期PRF结合臭氧注入更有效。
