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Abstract：
Cardiovascular magnetic resonance (CMR) is increasingly used in newborns with congenital heart disease. However, reporting on ventricular volumes and mass is hindered by an absence of normative data in this population.
Healthy term (37-41 weeks gestation) newborns underwent non-sedated, free-breathing CMR within the first week of life using the \'feed and wrap\' technique. End-diastolic volume (EDV), end-systolic volume (ESV) stroke volume (SV) and ejection fraction (EF) were calculated for both left ventricle (LV) and right ventricle (RV). Papillary muscles were separately contoured and included in the myocardial volume. Myocardial mass was calculated by multiplying myocardial volume by 1.05 g/ml. All data were indexed to weight and body surface area (BSA). Inter-observer variability (IOV) was performed on data from 10 randomly chosen infants.
Twenty healthy newborns (65% male) with a mean (SD) birth weight of 3.54 (0.46) kg and BSA of 0.23 (0.02) m2 were included. Normative LV parameters were indexed EDV 39.0 (4.1) ml/m2, ESV 14.5 (2.5) ml/m2 and ejection fraction (EF) 63.2 (3.4)%. Normative RV indexed EDV, ESV and EF were 47.4 (4.5) ml/m2, 22.6 (2.9) ml/m2 and 52.5 (3.3)% respectively. Mean LV and RV indexed mass were 26.4 (2.8) g/m2 and 12.5 (2.0) g/m2, respectively. There was no difference in ventricular volumes by gender. IOV was excellent with an intra-class coefficient > 0.95 except for RV mass (0.94).
This study provides normative data on LV and RV parameters in healthy newborns, providing a novel resource for comparison with newborns with structural and functional heart disease.
Healthy term (37-41 weeks gestation) newborns underwent non-sedated, free-breathing CMR within the first week of life using the \'feed and wrap\' technique. End-diastolic volume (EDV), end-systolic volume (ESV) stroke volume (SV) and ejection fraction (EF) were calculated for both left ventricle (LV) and right ventricle (RV). Papillary muscles were separately contoured and included in the myocardial volume. Myocardial mass was calculated by multiplying myocardial volume by 1.05 g/ml. All data were indexed to weight and body surface area (BSA). Inter-observer variability (IOV) was performed on data from 10 randomly chosen infants.
Twenty healthy newborns (65% male) with a mean (SD) birth weight of 3.54 (0.46) kg and BSA of 0.23 (0.02) m2 were included. Normative LV parameters were indexed EDV 39.0 (4.1) ml/m2, ESV 14.5 (2.5) ml/m2 and ejection fraction (EF) 63.2 (3.4)%. Normative RV indexed EDV, ESV and EF were 47.4 (4.5) ml/m2, 22.6 (2.9) ml/m2 and 52.5 (3.3)% respectively. Mean LV and RV indexed mass were 26.4 (2.8) g/m2 and 12.5 (2.0) g/m2, respectively. There was no difference in ventricular volumes by gender. IOV was excellent with an intra-class coefficient > 0.95 except for RV mass (0.94).
This study provides normative data on LV and RV parameters in healthy newborns, providing a novel resource for comparison with newborns with structural and functional heart disease.
摘要：
背景：心血管磁共振（CMR）越来越多地用于患有先天性心脏病的新生儿。然而,该人群缺乏规范数据阻碍了心室容积和质量的报告.
方法：健康足月（妊娠37-41周）新生儿接受非镇静治疗，在生命的第一周内使用“饲料和包装”技术进行自由呼吸CMR。舒张末期容积(EDV),计算左心室(LV)和右心室(RV)的收缩末期容积(ESV)每搏输出量(SV)和射血分数(EF).乳头状肌分别轮廓化，并包括在心肌体积中。通过将心肌体积乘以1.05g/ml来计算心肌质量。所有数据都以体重和体表面积(BSA)为索引。对10名随机选择的婴儿的数据进行观察者间变异性（IOV）。
结果：包括20名健康新生儿（65％为男性），平均（SD）出生体重为3.54（0.46）kg，BSA为0.23（0.02）m2。标准LV参数为EDV39.0（4.1）ml/m2，ESV14.5（2.5）ml/m2和射血分数（EF）63.2（3.4）％。规范性RV索引EDV，ESV和EF分别为47.4（4.5）ml/m2，22.6（2.9）ml/m2和52.5（3.3）％。平均LV和RV指数质量分别为26.4(2.8)g/m2和12.5(2.0)g/m2。不同性别的心室容积没有差异。除RV质量（0.94）外，IOV良好，类内系数>0.95。
结论：本研究提供了健康新生儿LV和RV参数的规范数据，为与患有结构性和功能性心脏病的新生儿进行比较提供了新的资源。
方法：健康足月（妊娠37-41周）新生儿接受非镇静治疗，在生命的第一周内使用“饲料和包装”技术进行自由呼吸CMR。舒张末期容积(EDV),计算左心室(LV)和右心室(RV)的收缩末期容积(ESV)每搏输出量(SV)和射血分数(EF).乳头状肌分别轮廓化，并包括在心肌体积中。通过将心肌体积乘以1.05g/ml来计算心肌质量。所有数据都以体重和体表面积(BSA)为索引。对10名随机选择的婴儿的数据进行观察者间变异性（IOV）。
结果：包括20名健康新生儿（65％为男性），平均（SD）出生体重为3.54（0.46）kg，BSA为0.23（0.02）m2。标准LV参数为EDV39.0（4.1）ml/m2，ESV14.5（2.5）ml/m2和射血分数（EF）63.2（3.4）％。规范性RV索引EDV，ESV和EF分别为47.4（4.5）ml/m2，22.6（2.9）ml/m2和52.5（3.3）％。平均LV和RV指数质量分别为26.4(2.8)g/m2和12.5(2.0)g/m2。不同性别的心室容积没有差异。除RV质量（0.94）外，IOV良好，类内系数>0.95。
结论：本研究提供了健康新生儿LV和RV参数的规范数据，为与患有结构性和功能性心脏病的新生儿进行比较提供了新的资源。
