METHODS: All available systematic reviews and meta-analyses on cystoscopy published in PubMed® between May 2010 and March 2021 were identified and reviewed. The main endpoints were clinical performance for bladder cancer diagnosis and for recurrence or progression detection during NMIBC follow-up, and additional value compared with cytology and/or WLC.
RESULTS: Most of the meta-analyses and systematic reviews published suggest a better sensitivity of BLC and NBI cystoscopy compared to WLC, particularly for the detection of flat lesions (CIS). NBI- and BLC-guided TURBT could decrease the recurrence rates. However, their clinical utility to reduce progression rate and increase survival is still unclear.
CONCLUSIONS: BLC and NBI cystoscopy are efficient techniques for bladder cancer diagnosis and NMIBC follow-up. However, their clinical benefit remains to be confirmed.
方法:确定并审查了2010年5月至2021年3月在PubMed®上发表的所有关于膀胱镜检查的系统评价和荟萃分析。主要终点是膀胱癌诊断和NMIBC随访期间复发或进展检测的临床表现,以及与细胞学和/或WLC相比的附加价值。
结果:发表的大多数荟萃分析和系统评价表明,与WLC相比,BLC和NBI膀胱镜检查的敏感性更好,特别是对于扁平病变(CIS)的检测。NBI和BLC引导的TURBT可降低复发率。然而,它们在降低进展率和增加生存率方面的临床效用尚不清楚.
结论:BLC和NBI膀胱镜检查是膀胱癌诊断和NMIBC随访的有效技术。然而,其临床获益仍有待证实。