{Reference Type}: Journal Article
{Title}: Photodynamic cystoscopy for bladder cancer diagnosis and for NMIBC follow-up: An overview of systematic reviews and meta-analyses.
{Author}: Soorojebally Y;Neuzillet Y;Lebret T;Allory Y;Descotes F;Ferlicot S;Kassab-Chahmi D;Lamy PJ;Oudard S;Rébillard X;Roy C;Roumiguié M;Rouprêt M;Audenet F;
{Journal}: Prog Urol
{Volume}: 33
{Issue}: 6
{Year}: 2023 May 21
{Factor}: 1.09
{DOI}: 10.1016/j.purol.2023.03.003
{Abstract}: <B>BACKGROUND: </B>Currently, bladder cancer detection is based on cytology and cystoscopy. White light cystoscopy (WLC) is an invasive procedure and may under-detect flat lesions. Blue light cystoscopy (BLC) and narrow band imaging (NBI) cystoscopy are new modalities that could improve the detection of non-muscle invasive bladder cancer (NMIBC) and its recurrence or progression to muscle invasive bladder cancer. We present a systematic review on BLC and NBI cystoscopy for bladder cancer diagnosis and NMIBC follow-up.<BR><B>METHODS: </B>All available systematic reviews and meta-analyses on cystoscopy published in PubMed® between May 2010 and March 2021 were identified and reviewed. The main endpoints were clinical performance for bladder cancer diagnosis and for recurrence or progression detection during NMIBC follow-up, and additional value compared with cytology and/or WLC.<BR><B>RESULTS: </B>Most of the meta-analyses and systematic reviews published suggest a better sensitivity of BLC and NBI cystoscopy compared to WLC, particularly for the detection of flat lesions (CIS). NBI- and BLC-guided TURBT could decrease the recurrence rates. However, their clinical utility to reduce progression rate and increase survival is still unclear.<BR><B>CONCLUSIONS: </B>BLC and NBI cystoscopy are efficient techniques for bladder cancer diagnosis and NMIBC follow-up. However, their clinical benefit remains to be confirmed.