Abstract：
UNASSIGNED: Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that disproportionately affects patients with skin of color. Genetic studies have revealed that approximately 30% of CCCAs are associated with peptidyl arginine deiminase 3 misfolding mutations. Patients with CCCA usually have a poor prognosis with progressive and permanent hair loss. To further characterize CCCA, we evaluated the inflammatory milieu, PDL1, and caspase 3 expression. The data support the idea of CCCA being a CD4-predominant T-cell process. The loss of PDL1 and increase in caspase 3 expression raises the possibility of involvement of the PD1/PDL1 pathway in CCCA.
摘要：
■中央离心性瘢痕性脱发（CCCA）是一种瘢痕性脱发，不成比例地影响肤色患者。遗传研究表明，大约30％的CCCA与肽基精氨酸脱亚胺酶3错误折叠突变有关。CCCA患者通常预后不良，进行性和永久性脱发。为了进一步表征CCCA，我们评估了炎症环境，PDL1和caspase3表达。数据支持CCCA是CD4占优势的T细胞过程的想法。PDL1的缺失和caspase3表达的增加增加了PD1/PDL1途径参与CCCA的可能性。
