{Reference Type}: Journal Article
{Title}: Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series.
{Author}: Smith SDB;Woddor N;Cassarino DS;Chen W;Clemetson N;Nava VE;
{Journal}: Am J Dermatopathol
{Volume}: 45
{Issue}: 6
{Year}: 2023 Jun 1
{Factor}: 1.319
{DOI}: 10.1097/DAD.0000000000002428
{Abstract}: <B>UNASSIGNED: </B>Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that disproportionately affects patients with skin of color. Genetic studies have revealed that approximately 30% of CCCAs are associated with peptidyl arginine deiminase 3 misfolding mutations. Patients with CCCA usually have a poor prognosis with progressive and permanent hair loss. To further characterize CCCA, we evaluated the inflammatory milieu, PDL1, and caspase 3 expression. The data support the idea of CCCA being a CD4-predominant T-cell process. The loss of PDL1 and increase in caspase 3 expression raises the possibility of involvement of the PD1/PDL1 pathway in CCCA.