%0 Journal Article
%T Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series.
%A Smith SDB
%A Woddor N
%A Cassarino DS
%A Chen W
%A Clemetson N
%A Nava VE
%J Am J Dermatopathol
%V 45
%N 6
%D 2023 Jun 1
%M 37074004
%F 1.319
%R 10.1097/DAD.0000000000002428
%X <B>UNASSIGNED: </B>Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that disproportionately affects patients with skin of color. Genetic studies have revealed that approximately 30% of CCCAs are associated with peptidyl arginine deiminase 3 misfolding mutations. Patients with CCCA usually have a poor prognosis with progressive and permanent hair loss. To further characterize CCCA, we evaluated the inflammatory milieu, PDL1, and caspase 3 expression. The data support the idea of CCCA being a CD4-predominant T-cell process. The loss of PDL1 and increase in caspase 3 expression raises the possibility of involvement of the PD1/PDL1 pathway in CCCA.