关键词: CNV MAR disseminated melanoma retinal neovascularization vitreous haemorrhage

Mesh : Humans Male Middle Aged Melanoma / diagnosis complications Vitreous Hemorrhage / diagnosis etiology Ischemia / diagnosis etiology Retinal Neovascularization / diagnosis etiology Visual Acuity / physiology Retrospective Studies Fluorescein Angiography Skin Neoplasms / diagnosis Magnetic Resonance Imaging Laser Coagulation Ipilimumab / therapeutic use Tomography, Optical Coherence Retinal Vessels / pathology Tomography, X-Ray Computed

来  源:   DOI:10.1080/09273948.2023.2198003

Abstract:
UNASSIGNED: We describe a case of vitreous haemorrhage and retinal neovascularization secondary to peripheral retinal ischemia associated with disseminated melanoma.
UNASSIGNED: A retrospective case report.
UNASSIGNED: A 48-year-old man presented with vitreous haemorrhage in the right eye, peripheral retinal ischemia, and retinal neovascularization in both eyes. CT and MRI scans were suggestive of disseminated malignancy and an ultrasound-guided biopsy of the abdominal mass confirmed metastatic melanoma. Immune checkpoint inhibitor therapy with ipilimumab/nivolumab was initiated. Regarding his ocular status, the vitreous haemorrhage cleared spontaneously, visual acuity improved to 6/7.5 and the patient underwent bilateral peripheral scatter laser photocoagulation to stabilize the retinopathy. The patient passed away 1 year after the initial presentation.
UNASSIGNED:  Our patient presented with melanoma and peripheral retinal ischaemia, leading to retinal neovascularization and vitreous haemorrhage. Therefore, melanoma should be considered as a differential diagnosis when investigating the aetiology of peripheral retinal ischaemia.
摘要:
我们描述了一例玻璃体出血和继发于周围视网膜缺血的视网膜新生血管形成的病例,伴有弥漫性黑色素瘤。
回顾性病例报告。
一名48岁男子右眼出现玻璃体出血,周边视网膜缺血,和两只眼睛的视网膜新生血管。CT和MRI扫描提示播散的恶性肿瘤和腹部肿块的超声引导活检证实的转移性黑色素瘤。伊匹单抗/纳武单抗免疫检查点抑制剂治疗开始。关于他的眼部状况,玻璃体出血自发清除,视力改善至6/7.5,患者接受了双侧外周散射激光光凝以稳定视网膜病变.患者在初次就诊后1年去世。
我们的患者表现为黑色素瘤和周边视网膜缺血,导致视网膜新生血管形成和玻璃体出血。因此,在研究周围视网膜缺血的病因时,应将黑色素瘤视为鉴别诊断。
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