Abstract：
One new sesquiterpene, (6S,7R,11S)-13-carboxy-1(10)-en-dihydroartemisinic acid (1), together with three known sesquiterpenes, ainsliaea acid B (2), mongolicumin B (3), and 11β,13-dihydroxydeacetylmatricarin (4) were isolated from Taraxacum mongolicum Hand.-Mazz. The structures were established on the basis of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopy, ECD spectroscopy, and X-ray diffraction analysis. Compound 1 was found to have potential anti-inflammatory activity and could reduce LPS-induced NO levels in murine macrophage, with inhibitory rate of 37%.
摘要：
一种新的倍半萜,(6S,7R,11S)-13-羧基-1(10)-烯-二氢青蒿酸(1)，连同三种已知的倍半萜,甲磺酸B(2)，蒙古木素B(3)，和11β，从蒲公英中分离得到13-二羟基脱乙酰马曲素(4)。-爵士.结构建立在UV的基础上，IR,HR-ESI-MS,1D和2DNMR光谱，ECD光谱学，和X射线衍射分析。发现化合物1具有潜在的抗炎活性，可以降低小鼠巨噬细胞中LPS诱导的NO水平，抑制率为37%。
