Abstract：
Comprehension of thermal behavior underlying the living biological tissues helps successful applications of current heat therapies. The present work is to explore the heat transport properties of irradiated tissue during tis thermal treatment, in which the local thermal non-equilibrium effect as well as temperature-dependent properties arose from complicated anatomical structure, is considered. Based on the generalized dual-phase lag (GDPL) model, a non-linear governing equation of tissue temperature with variable thermal physical properties is proposed. The effective procedure constructed on an explicit finite difference scheme is then developed to predict numerically the thermal response and thermal damage irradiated by a pulse laser as a therapeutic heat source. The parametric study on variable thermal physical parameters including the phase lag times, heat conductivity, specific heat capacity and blood perfusion rate has been performed to evaluate their influence on temperature distribution in time and space. On this basis, the thermal damage with different laser variables such as laser intensity and exposure time are further analyzed.
摘要：
理解活体生物组织的热行为有助于当前热疗法的成功应用。目前的工作是探索热治疗过程中辐照组织的热传输特性，其中局部热非平衡效应以及温度相关特性来自复杂的解剖结构，被考虑。基于广义双相滞后(GDPL)模型，提出了具有可变热物理性质的组织温度的非线性控制方程。然后开发了在显式有限差分方案上构建的有效程序，以数值预测脉冲激光作为治疗热源所照射的热响应和热损伤。包括相位滞后时间在内的可变热物理参数的参数研究，导热性，已经进行了比热容和血液灌注率，以评估它们对时间和空间温度分布的影响。在此基础上,进一步分析了激光强度和曝光时间等不同激光变量对热损伤的影响。
