Abstract：
Psychiatric and metabolic disorders are highly comorbid and the relationship between these disorders is bidirectional. The mechanisms underlying the association between psychiatric and metabolic disorders are presently unclear, which warrants investigation into the dynamics of the interplay between metabolism, substrate utilization, and energy expenditure in psychiatric populations, and how these constructs compare to those in healthy controls. Indirect calorimetry (IC) methods are a reliable, minimally invasive means for assessing metabolic rate and substrate utilization in humans. This review synthesizes the extant literature on the use of IC on resting metabolism in psychiatric populations to investigate the interaction between psychiatric and metabolic functioning. Consistently, resting energy expenditures and/or substrate utilization values were significantly different between psychiatric and healthy populations in the studies contained in this review. Furthermore, resting energy expenditure values were systematically overestimated when derived from predictive equations, compared to when measured by IC, in psychiatric populations. High heterogeneity between study populations (e.g., differing diagnoses and drug regimens) and methodologies (e.g., differing posture, time of day, and fasting status at measurement) impeded the synthesis of results. Standardized IC protocols would benefit this line of research by enabling meta-analyses, revealing trends within and between different psychiatric disorders.
摘要：
精神病和代谢紊乱是高度合并症，并且这些疾病之间的关系是双向的。目前尚不清楚精神病和代谢紊乱之间关联的潜在机制。这需要对新陈代谢之间相互作用的动力学进行研究，底物利用率，和精神科人群的能量消耗，以及这些结构如何与健康对照中的结构进行比较。间接量热法（IC）方法是一种可靠的，评估人体代谢率和底物利用率的微创手段。这篇综述综合了有关在精神病人群中使用IC进行静息代谢的现有文献，以研究精神病与代谢功能之间的相互作用。始终如一，在本综述所包含的研究中,精神病人群和健康人群的静息能量消耗和/或底物利用值存在显著差异.此外，当从预测方程推导出时，静息能量消耗值被系统地高估了，与通过IC测量时相比，在精神病人群中。研究人群之间的高度异质性(例如，不同的诊断和药物方案)和方法(例如，不同的姿势，一天的时间,和测量时的空腹状态)阻碍了结果的综合。标准化的IC协议将通过实现荟萃分析而有益于这一系列研究，揭示不同精神疾病内部和之间的趋势。
