Abstract：
Curcuma is a world-renowned herb known for its immense health benefits. In this study, physicochemical analyses were performed on the curcumin standard sample and curcumin multiple emulsions. The emulsions were analysed for thermal and structural stability for 21 days. Confocal laser microscopy (CLSM) was performed in order to observe the emulsion encapsulation. Modulated differential scanning calorimetry (MDSC) and HPLC methods revealed a variety of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin) in the investigated curcumin standard. In addition, the MDSC method was found to be suitable and comparable to HPLC for determining the curcuminoid substances. The analysis of the curcumin release revealed a value of 0.18 w.% after 14 days as the equilibrium value. Furthermore, an increase in the sizes of the emulsions was observed at the end of the 21-day study. The emulsion stability index (ESI) was used to measure the stability of multiple emulsions. The ESI reached 55.8% between 7 and 21 days later. Nano droplets of the oil phase loaded with dispersed curcumin particles captured inside the water-based carboxymethylcellulose micelles were clearly observed by CLSM.
摘要：
姜黄是一种世界知名的草药，以其巨大的健康益处而闻名。在这项研究中,对姜黄素标准样品和姜黄素多重乳剂进行理化分析.分析乳液21天的热稳定性和结构稳定性。进行共聚焦激光显微镜(CLSM)以观察乳液包封。调制差示扫描量热法（MDSC）和HPLC方法揭示了多种姜黄素（姜黄素，去甲氧基姜黄素,双去甲氧基姜黄素,和cyclocurcumin）在研究的姜黄素标准中。此外,发现MDSC方法对于测定类姜黄素物质是合适的并且与HPLC相当。姜黄素释放的分析显示,14天后的平衡值为0.18重量%。此外，在21天研究结束时,观察到乳剂大小增加.乳液稳定性指数(ESI)用于测量多重乳液的稳定性。ESI在7到21天后达到55.8%。通过CLSM清楚地观察到在水基羧甲基纤维素胶束内捕获的负载有分散的姜黄素颗粒的油相的纳米液滴。
