PDF(Pubmed)
Abstract：
Invasive pulmonary aspergillosis remains a major cause of morbidity and mortality for immunocompromised children, particularly for patients with acute leukaemia and those undergoing haematopoietic stem cell transplantation. Timely diagnosis, using a combination of computed tomography (CT) imaging and microbiological testing, is key to improve prognosis, yet there are inherent challenges in this process. For CT imaging, changes in children are generally less specific than those reported in adults and recent data are limited. Respiratory sampling by either bronchoalveolar lavage or lung biopsy is recommended but is not always feasible in children, and serum biomarkers, including galactomannan, have important limitations. In this review we summarise the current paediatric data on available diagnostic tests for IPA and highlight key emerging diagnostic modalities with potential for future use.
摘要：
侵袭性肺曲霉病仍然是免疫功能低下儿童发病和死亡的主要原因。特别是对于急性白血病患者和接受造血干细胞移植的患者。及时诊断,使用计算机断层扫描（CT）成像和微生物测试的组合，是改善预后的关键，然而，在这个过程中存在固有的挑战。对于CT成像，儿童的变化通常不如成人报告的变化那么具体，最近的数据有限。建议通过支气管肺泡灌洗或肺活检进行呼吸道采样，但在儿童中并不总是可行的。和血清生物标志物，包括半乳甘露聚糖,有重要的局限性。在这篇综述中，我们总结了当前有关IPA可用诊断测试的儿科数据，并重点介绍了具有未来使用潜力的关键新兴诊断方式。
