PDF(Pubmed)
Abstract：
The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity.
摘要：
SARS-CoV-2的尖峰（S）蛋白正在快速进化，在病毒免疫逃逸中起着至关重要的作用，传染性，和可传播性。为了获得临床洞察力，Dadonaite等人。开发了一种新型的深度突变扫描（DMS）平台，用于绘制S蛋白突变对免疫逃避和病毒感染性的影响。
