Abstract：
Aspirin exacerbated respiratory disease (AERD) is a condition caused by increased bronchoconstriction in people with asthma after taking aspirin or another NSAID. Molecular analysis of the human genome has opened up new perspectives on human polymorphisms and disease. This study was conducted to identify the genetic factors that influence this disease due to its unknown genetic factors. We evaluated research studies, letters, comments, editorials, eBooks, and reviews. PubMed/MEDLINE, Web of Sciences, Cochrane Library, and Scopus were searched for information. We used the keywords polymorphisms, aspirin-exacerbated respiratory disease, asthma, allergy as search terms. This study included 38 studies. AERD complications were associated with polymorphisms in ALOX15, EP2, ADRB2, SLC6A12, CCR3, CRTH2, CysLTs, DPCR1, DPP10, FPR2, HSP70, IL8, IL1B, IL5RA, IL-13, IL17RA, ILVBL, TBXA2R, TLR3, HLA-DRB and HLA-DQ, HLA-DR7, HLA-DP. AERD was associated with heterogeneity in gene polymorphisms, making it difficult to pinpoint specific gene changes. Therefore, diagnosing and treating AERD may be facilitated by examining common variants involving the disease.
摘要：
阿司匹林加重呼吸道疾病（AERD）是哮喘患者服用阿司匹林或其他NSAID后支气管收缩增加引起的疾病。人类基因组的分子分析开辟了人类多态性和疾病的新观点。进行这项研究是为了确定由于未知的遗传因素而影响这种疾病的遗传因素。我们评估了研究，信件,注释,社论,电子书,和评论。PubMed/MEDLINE,WebofSciences,科克伦图书馆,和Scopus被搜索信息。我们使用了关键词多态性，阿司匹林加剧了呼吸系统疾病，哮喘,过敏作为搜索条件。这项研究包括38项研究。AERD并发症与ALOX15、EP2、ADRB2、SLC6A12、CCR3、CRTH2、CysLTs、DPCR1,DPP10,FPR2,HSP70,IL8,IL1B,IL5RA,IL-13,IL17RA,ILVBL,TBXA2R,TLR3,HLA-DRB和HLA-DQ,HLA-DR7，HLA-DP。AERD与基因多态性的异质性有关，很难确定特定的基因变化。因此,诊断和治疗AERD可以通过检查涉及该疾病的常见变异来促进.
