PDF(Pubmed)
Abstract：
Etomidate is an imidazole derivative that is widely used in the emergency department for Rapid Sequence Intubation (RSI). Although it has a safe hemodynamic profile, there are some concerns about its suppressant effects on the adreno-cortical axis. Vitamin C, as an antioxidant, can play a protective role in this issue.
In a controlled clinical trial, we studied adult traumatic patients who needed RSI with etomidate. In one group underwent RSI with etomidate and cortisol levels were measured three hours later. In the other group, we administered one gram of vitamin C before etomidate administration, and the cortisol level was measured three hours later.
Fifty-one patients have been studied. The serum cortisol level was significantly lower after RSI with etomidate in both groups. In the Vitamin C group, there was a significantly higher cortisol level after RSI in comparison to the control group.
Etomidate can suppress the cortisol level in trauma patients who undergo RSI. Vitamin C can reduce this suppressant effect of etomidate.
IRCT registration number: IRCT20090923002496N11, URL of trial registry record: https://en.irct.ir/trial/34586 , Date of trial registration: 19/04/2019. Full date of the first registration: 30/05/2019.
In a controlled clinical trial, we studied adult traumatic patients who needed RSI with etomidate. In one group underwent RSI with etomidate and cortisol levels were measured three hours later. In the other group, we administered one gram of vitamin C before etomidate administration, and the cortisol level was measured three hours later.
Fifty-one patients have been studied. The serum cortisol level was significantly lower after RSI with etomidate in both groups. In the Vitamin C group, there was a significantly higher cortisol level after RSI in comparison to the control group.
Etomidate can suppress the cortisol level in trauma patients who undergo RSI. Vitamin C can reduce this suppressant effect of etomidate.
IRCT registration number: IRCT20090923002496N11, URL of trial registry record: https://en.irct.ir/trial/34586 , Date of trial registration: 19/04/2019. Full date of the first registration: 30/05/2019.
摘要：
背景：依托咪酯是一种咪唑衍生物，在急诊科中广泛用于快速序列插管（RSI）。虽然它有安全的血液动力学特征，有一些关于它对肾上腺皮质轴的抑制作用的担忧。维生素C,作为一种抗氧化剂，可以在这个问题上起到保护作用。
方法：在一项对照临床试验中，我们研究了需要使用依托咪酯治疗RSI的成年创伤患者.在一组接受依托咪酯的RSI中，三小时后测量皮质醇水平。在另一组中，我们在服用依托咪酯之前服用了一克维生素C，三小时后测量皮质醇水平。
结果：研究了51例患者。两组在使用依托咪酯的RSI后血清皮质醇水平均显着降低。在维生素C组中，RSI后皮质醇水平明显高于对照组.
结论：依托咪酯可以抑制RSI创伤患者的皮质醇水平。维生素C可以降低依托咪酯的这种抑制作用。
背景：IRCT注册号：IRCT20090923002496N11，试验注册记录的URL：https://en。irct.ir/trial/34586,试用登记日期：2019-19-04首次注册的完整日期：2019年5月30日。
方法：在一项对照临床试验中，我们研究了需要使用依托咪酯治疗RSI的成年创伤患者.在一组接受依托咪酯的RSI中，三小时后测量皮质醇水平。在另一组中，我们在服用依托咪酯之前服用了一克维生素C，三小时后测量皮质醇水平。
结果：研究了51例患者。两组在使用依托咪酯的RSI后血清皮质醇水平均显着降低。在维生素C组中，RSI后皮质醇水平明显高于对照组.
结论：依托咪酯可以抑制RSI创伤患者的皮质醇水平。维生素C可以降低依托咪酯的这种抑制作用。
背景：IRCT注册号：IRCT20090923002496N11，试验注册记录的URL：https://en。irct.ir/trial/34586,试用登记日期：2019-19-04首次注册的完整日期：2019年5月30日。
