Abstract：
Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period.
摘要：
甲基乙二醛（MGO）被认为是负责Leptospermum种的抗菌活性的重要成分之一。（麦卢卡）蜂蜜。虽然许多研究已经证明了MGO在体外的剂量依赖性抗菌活性，从治疗的角度来看，确认其从麦卢卡蜂蜜和麦卢卡蜂蜜配方中的释放也很重要。这项研究是首次使用Franz扩散池和高效液相色谱（HPLC）分析报告含有麦卢卡蜂蜜的五种商业产品中MGO的释放曲线。在12小时内监测MGO的释放，以MGO含量的释放百分比表示，发现人造蜂蜜基质和NZManuka蜂蜜的释放率为99.49％和98.05％。分别。对于所研究的配方，在12小时的研究期间，MGO释放时间依赖性百分比在85％至97.18％之间。
